Navigation in individuals at risk for Alzheimer's disease

Spatial navigation has become increasingly relevant in at-risk Alzheimer's disease. The main reason is that the brain's spatial navigation network largely overlaps with areas affected by Alzheimer's disease pathophysiology, even potentially before memory symptoms emerge. In this article, we will briefly outline how Alzheimer's pathophysiology can affect spatial navigation networks in the brain. The remainder of the article will be exploring how prodromal and preclinical, sporadic- and genetic-risk for Alzheimer's disease affect spatial navigation performance before exploring the real-world diagnostic and management implications of those findings, as well as future directions the field is considering.