Neural crest cells organize the eye via TGF-β and canonical Wnt signalling

Timothy Grocott, Samuel Johnson, Andrew P. Bailey, Andrea Streit

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)

Abstract

In vertebrates, the lens and retina arise from different embryonic tissues raising the question of how they are aligned to form a functional eye. Neural crest cells are crucial for this process: in their absence, ectopic lenses develop far from the retina. Here we show, using the chick as a model system, that neural crest-derived transforming growth factor-ßs activate both Smad3 and canonical Wnt signalling in the adjacent ectoderm to position the lens next to the retina. They do so by controlling Pax6 activity: although Smad3 may inhibit Pax6 protein function, its sustained downregulation requires transcriptional repression by Wnt-initiated ß-catenin. We propose that the same neural crest-dependent signalling mechanism is used repeatedly to integrate different components of the eye and suggest a general role for the neural crest in coordinating central and peripheral parts of the sensory nervous system.
Original languageEnglish
Pages (from-to)265
Number of pages1
JournalNature Communications
Volume2
DOIs
Publication statusPublished - 5 Apr 2011

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