TY - JOUR
T1 - Neuropsychiatric symptoms in behavioral variant frontotemporal dementia and Alzheimer's disease: A 12-month follow-up study
AU - Da Silva, Thais Bento Lima
AU - Ordonez, Tiago Nascimento
AU - Bregola, Allan Gustavo
AU - Bahia, Valéria Santoro
AU - Cecchini, Mário Amore
AU - Guimarães, Henrique Cerqueira
AU - Gambogi, Leandro Boson
AU - Caramelli, Paulo
AU - Balthazar, Marcio Luiz Figueredo
AU - Damasceno, Benito Pereira
AU - Brucki, Sonia Maria Dozzi
AU - De Souza, Leonardo Cruz
AU - Nitrini, Ricardo
AU - Yassuda, Monica Sanches
N1 - Funding Information: This project was supported by the São Paulo Research Foundation (FAPESP) Grant Number: 11/04804-1 and 16/07967-2. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Grant Number: 151684/2014-6 and by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Grant Number: 88881.131619/2016-01.
PY - 2021/9/30
Y1 - 2021/9/30
N2 - Introduction: Neuropsychiatric symptoms in patients with frontotemporal dementia (FTD) are highly prevalent and may complicate clinical managements. Objective: To test whether the Neuropsychiatry Inventory (NPI) could detect change in neuropsychiatric symptoms and caregiver's distress in patients diagnosed with behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) from baseline to a 12-month follow-up and to investigate possible predictors of change in NPI scores. Methods: The sample consisted of 31 patients diagnosed with bvFTD and 28 patients with AD and their caregivers. The Mini-Mental State Examination (MMSE), Addenbrooke's Cognitive Examination Revised (ACE-R), the INECO Frontal Screening (IFS), the Frontal Assessment Battery (FAB), the Executive Interview (EXIT-25) and the NPI were applied. Descriptive statistics, Mann-Whitney U test, Wilcoxon test, Chi square (χ 2) test and Linear Regression Analysis were used. Results: NPI total and caregiver distress scores were statistically higher among bvFTD patients at both assessment points. MMSE, ACE-R scores significantly declined and NPI Total and Distress scores significantly increased in both groups. In the bvFTD group, age was the only independent predictor variable for the NPI total score at follow up. In the AD group, ACE-R and EXIT-25, conjunctively, were associated with the NPI total score at follow up. Conclusions: In 12 months, cognition declined and neuropsychiatric symptoms increased in bvFTD and AD groups. In the AD group only, cognitive impairment was a significant predictor of change in neuropsychiatric symptoms.
AB - Introduction: Neuropsychiatric symptoms in patients with frontotemporal dementia (FTD) are highly prevalent and may complicate clinical managements. Objective: To test whether the Neuropsychiatry Inventory (NPI) could detect change in neuropsychiatric symptoms and caregiver's distress in patients diagnosed with behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) from baseline to a 12-month follow-up and to investigate possible predictors of change in NPI scores. Methods: The sample consisted of 31 patients diagnosed with bvFTD and 28 patients with AD and their caregivers. The Mini-Mental State Examination (MMSE), Addenbrooke's Cognitive Examination Revised (ACE-R), the INECO Frontal Screening (IFS), the Frontal Assessment Battery (FAB), the Executive Interview (EXIT-25) and the NPI were applied. Descriptive statistics, Mann-Whitney U test, Wilcoxon test, Chi square (χ 2) test and Linear Regression Analysis were used. Results: NPI total and caregiver distress scores were statistically higher among bvFTD patients at both assessment points. MMSE, ACE-R scores significantly declined and NPI Total and Distress scores significantly increased in both groups. In the bvFTD group, age was the only independent predictor variable for the NPI total score at follow up. In the AD group, ACE-R and EXIT-25, conjunctively, were associated with the NPI total score at follow up. Conclusions: In 12 months, cognition declined and neuropsychiatric symptoms increased in bvFTD and AD groups. In the AD group only, cognitive impairment was a significant predictor of change in neuropsychiatric symptoms.
KW - Alzheimer's disease (AD)
KW - aging
KW - behavioral dementia frontotemporal (bvFTD)
KW - elderly
KW - neuropsychiatric symptoms
UR - http://www.scopus.com/inward/record.url?scp=85117154928&partnerID=8YFLogxK
U2 - 10.3389/fneur.2021.728108
DO - 10.3389/fneur.2021.728108
M3 - Article
VL - 12
JO - Frontiers in Neurology
JF - Frontiers in Neurology
SN - 1664-2295
M1 - 728108
ER -