Neutrophil superoxide anion--generating capacity, endothelial function and oxidative stress in chronic heart failure: effects of short- and long-term vitamin C therapy

Gethin R. Ellis, Richard A. Anderson, Derek Lang, Daniel J. Blackman, R. H. Keith Morris, Jayne Morris-Thurgood, Ian F. W. McDowell, Simon K. Jackson, Malcolm J. Lewis, Michael P. Frenneaux

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120 Citations (Scopus)

Abstract

First, we sought to study the effects of short- and long-term vitamin C therapy on oxidative stress and endothelial dysfunction in chronic heart failure (CHF), and second, we sought to investigate the role of neutrophils as a cause of oxidative stress in CHF.
Original languageEnglish
Pages (from-to)1474-82
Number of pages9
JournalJournal of the American College of Cardiology
Volume36
Issue number5
DOIs
Publication statusPublished - 1 Nov 2000

Keywords

  • Anions
  • Ascorbic Acid
  • Chronic Disease
  • Endothelium
  • Female
  • Heart Failure
  • Humans
  • Male
  • Neutrophils
  • Oxidative Stress
  • Superoxides
  • Time Factors

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