Neutrophil superoxide anion--generating capacity, endothelial function and oxidative stress in chronic heart failure: effects of short- and long-term vitamin C therapy

Gethin R. Ellis; Richard A. Anderson; Derek Lang; Daniel J. Blackman; R. H. Keith Morris; Jayne Morris-Thurgood; Ian F. W. McDowell; Simon K. Jackson; Malcolm J. Lewis; Michael P. Frenneaux

doi:10.1016/S0735-1097(00)00916-5

Neutrophil superoxide anion--generating capacity, endothelial function and oxidative stress in chronic heart failure: effects of short- and long-term vitamin C therapy

Gethin R. Ellis, Richard A. Anderson, Derek Lang, Daniel J. Blackman, R. H. Keith Morris, Jayne Morris-Thurgood, Ian F. W. McDowell, Simon K. Jackson, Malcolm J. Lewis, Michael P. Frenneaux

Research output: Contribution to journal › Article › peer-review

129 Citations (Scopus)

Abstract

First, we sought to study the effects of short- and long-term vitamin C therapy on oxidative stress and endothelial dysfunction in chronic heart failure (CHF), and second, we sought to investigate the role of neutrophils as a cause of oxidative stress in CHF.

Original language	English
Pages (from-to)	1474-82
Number of pages	9
Journal	Journal of the American College of Cardiology
Volume	36
Issue number	5
DOIs	https://doi.org/10.1016/S0735-1097(00)00916-5
Publication status	Published - 1 Nov 2000

Keywords

Anions
Ascorbic Acid
Chronic Disease
Endothelium
Female
Heart Failure
Humans
Male
Neutrophils
Oxidative Stress
Superoxides
Time Factors

Access to Document

10.1016/S0735-1097(00)00916-5Licence: Other

Cite this

Ellis, G. R., Anderson, R. A., Lang, D., Blackman, D. J., Morris, R. H. K., Morris-Thurgood, J., McDowell, I. F. W., Jackson, S. K., Lewis, M. J., & Frenneaux, M. P. (2000). Neutrophil superoxide anion--generating capacity, endothelial function and oxidative stress in chronic heart failure: effects of short- and long-term vitamin C therapy. Journal of the American College of Cardiology, 36(5), 1474-82. https://doi.org/10.1016/S0735-1097(00)00916-5

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title = "Neutrophil superoxide anion--generating capacity, endothelial function and oxidative stress in chronic heart failure: effects of short- and long-term vitamin C therapy",

abstract = "First, we sought to study the effects of short- and long-term vitamin C therapy on oxidative stress and endothelial dysfunction in chronic heart failure (CHF), and second, we sought to investigate the role of neutrophils as a cause of oxidative stress in CHF.",

keywords = "Anions, Ascorbic Acid, Chronic Disease, Endothelium, Female, Heart Failure, Humans, Male, Neutrophils, Oxidative Stress, Superoxides, Time Factors",

author = "Ellis, {Gethin R.} and Anderson, {Richard A.} and Derek Lang and Blackman, {Daniel J.} and Morris, {R. H. Keith} and Jayne Morris-Thurgood and McDowell, {Ian F. W.} and Jackson, {Simon K.} and Lewis, {Malcolm J.} and Frenneaux, {Michael P.}",

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Ellis, GR, Anderson, RA, Lang, D, Blackman, DJ, Morris, RHK, Morris-Thurgood, J, McDowell, IFW, Jackson, SK, Lewis, MJ & Frenneaux, MP 2000, 'Neutrophil superoxide anion--generating capacity, endothelial function and oxidative stress in chronic heart failure: effects of short- and long-term vitamin C therapy', Journal of the American College of Cardiology, vol. 36, no. 5, pp. 1474-82. https://doi.org/10.1016/S0735-1097(00)00916-5

Neutrophil superoxide anion--generating capacity, endothelial function and oxidative stress in chronic heart failure: effects of short- and long-term vitamin C therapy. / Ellis, Gethin R.; Anderson, Richard A.; Lang, Derek et al.
In: Journal of the American College of Cardiology, Vol. 36, No. 5, 01.11.2000, p. 1474-82.

Research output: Contribution to journal › Article › peer-review

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AU - Ellis, Gethin R.

AU - Anderson, Richard A.

AU - Lang, Derek

AU - Blackman, Daniel J.

AU - Morris, R. H. Keith

AU - Morris-Thurgood, Jayne

AU - McDowell, Ian F. W.

AU - Jackson, Simon K.

AU - Lewis, Malcolm J.

AU - Frenneaux, Michael P.

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AB - First, we sought to study the effects of short- and long-term vitamin C therapy on oxidative stress and endothelial dysfunction in chronic heart failure (CHF), and second, we sought to investigate the role of neutrophils as a cause of oxidative stress in CHF.

KW - Anions

KW - Ascorbic Acid

KW - Chronic Disease

KW - Endothelium

KW - Female

KW - Heart Failure

KW - Humans

KW - Male

KW - Neutrophils

KW - Oxidative Stress

KW - Superoxides

KW - Time Factors

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