New Insights into the Mechanism of Enzymatic Chlorination of Tryptophan

Silvana Flecks, Eugenio P. Patallo, Xiaofeng Zhu, Aliz J. Ernyei, Gotthard Seifert, Alexander Schneider, Changjiang Dong, James H. Naismith, Karl-Heinz van Pée

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Abstract

(Chemical Equation Presented) It takes two: Both a lysine and a glutamate residue in the active site of tryptophan halogenase are essential for its chlorination activity. A mechanism for the regioselective enzymatic chlorination of tryptophan involving both amino acids is suggested (see scheme). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
Original languageEnglish
Pages (from-to)9533-9536
Number of pages4
JournalAngewandte Chemie International Edition
Volume47
Issue number49
DOIs
Publication statusPublished - 24 Nov 2008

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