New insights into the mechanism of enzymatic chlorination of Tryptophan

Silvana Flecks; Eugenio P. Patallo; Xiaofeng Zhu; Aliz J. Ernyei; Gotthard Seifert; Alexander Schneider; Changjiang Dong; James H. Naismith; Karl-Heinz van Pée

doi:10.1002/anie.200802466

New insights into the mechanism of enzymatic chlorination of Tryptophan

Silvana Flecks
, Eugenio P. Patallo
, Xiaofeng Zhu
, Aliz J. Ernyei
, Gotthard Seifert
, Alexander Schneider
, Changjiang Dong
, James H. Naismith
, Karl-Heinz van Pée

Research output: Contribution to journal › Article › peer-review

114 Citations (Scopus)

Abstract

(Chemical Equation Presented) It takes two: Both a lysine and a glutamate residue in the active site of tryptophan halogenase are essential for its chlorination activity. A mechanism for the regioselective enzymatic chlorination of tryptophan involving both amino acids is suggested (see scheme). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

Original language	English
Pages (from-to)	9533-9536
Number of pages	4
Journal	Angewandte Chemie-International Edition
Volume	47
Issue number	49
DOIs	https://doi.org/10.1002/anie.200802466
Publication status	Published - 24 Nov 2008

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10.1002/anie.200802466

Cite this

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abstract = "(Chemical Equation Presented) It takes two: Both a lysine and a glutamate residue in the active site of tryptophan halogenase are essential for its chlorination activity. A mechanism for the regioselective enzymatic chlorination of tryptophan involving both amino acids is suggested (see scheme). {\textcopyright} 2008 Wiley-VCH Verlag GmbH \& Co. KGaA.",

author = "Silvana Flecks and Patallo, \{Eugenio P.\} and Xiaofeng Zhu and Ernyei, \{Aliz J.\} and Gotthard Seifert and Alexander Schneider and Changjiang Dong and Naismith, \{James H.\} and \{van P{\'e}e\}, Karl-Heinz",

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AU - Flecks, Silvana

AU - Patallo, Eugenio P.

AU - Zhu, Xiaofeng

AU - Ernyei, Aliz J.

AU - Seifert, Gotthard

AU - Schneider, Alexander

AU - Dong, Changjiang

AU - Naismith, James H.

AU - van Pée, Karl-Heinz

PY - 2008/11/24

Y1 - 2008/11/24

N2 - (Chemical Equation Presented) It takes two: Both a lysine and a glutamate residue in the active site of tryptophan halogenase are essential for its chlorination activity. A mechanism for the regioselective enzymatic chlorination of tryptophan involving both amino acids is suggested (see scheme). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

AB - (Chemical Equation Presented) It takes two: Both a lysine and a glutamate residue in the active site of tryptophan halogenase are essential for its chlorination activity. A mechanism for the regioselective enzymatic chlorination of tryptophan involving both amino acids is suggested (see scheme). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

U2 - 10.1002/anie.200802466

DO - 10.1002/anie.200802466

M3 - Article

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VL - 47

SP - 9533

EP - 9536

JO - Angewandte Chemie-International Edition

JF - Angewandte Chemie-International Edition

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