New insights into the mechanism of enzymatic chlorination of Tryptophan

Silvana Flecks; Eugenio P. Patallo; Xiaofeng Zhu; Aliz J. Ernyei; Gotthard Seifert; Alexander Schneider; Changjiang Dong; James H. Naismith; Karl-Heinz van Pée

doi:10.1002/anie.200802466

New insights into the mechanism of enzymatic chlorination of Tryptophan

Silvana Flecks, Eugenio P. Patallo, Xiaofeng Zhu, Aliz J. Ernyei, Gotthard Seifert, Alexander Schneider, Changjiang Dong, James H. Naismith, Karl-Heinz van Pée

Research output: Contribution to journal › Article › peer-review

111 Citations (Scopus)

Abstract

(Chemical Equation Presented) It takes two: Both a lysine and a glutamate residue in the active site of tryptophan halogenase are essential for its chlorination activity. A mechanism for the regioselective enzymatic chlorination of tryptophan involving both amino acids is suggested (see scheme). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

Original language	English
Pages (from-to)	9533-9536
Number of pages	4
Journal	Angewandte Chemie-International Edition
Volume	47
Issue number	49
DOIs	https://doi.org/10.1002/anie.200802466
Publication status	Published - 24 Nov 2008

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10.1002/anie.200802466

Cite this

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title = "New insights into the mechanism of enzymatic chlorination of Tryptophan",

abstract = "(Chemical Equation Presented) It takes two: Both a lysine and a glutamate residue in the active site of tryptophan halogenase are essential for its chlorination activity. A mechanism for the regioselective enzymatic chlorination of tryptophan involving both amino acids is suggested (see scheme). {\textcopyright} 2008 Wiley-VCH Verlag GmbH & Co. KGaA.",

author = "Silvana Flecks and Patallo, {Eugenio P.} and Xiaofeng Zhu and Ernyei, {Aliz J.} and Gotthard Seifert and Alexander Schneider and Changjiang Dong and Naismith, {James H.} and {van P{\'e}e}, Karl-Heinz",

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AU - Flecks, Silvana

AU - Patallo, Eugenio P.

AU - Zhu, Xiaofeng

AU - Ernyei, Aliz J.

AU - Seifert, Gotthard

AU - Schneider, Alexander

AU - Dong, Changjiang

AU - Naismith, James H.

AU - van Pée, Karl-Heinz

PY - 2008/11/24

Y1 - 2008/11/24

N2 - (Chemical Equation Presented) It takes two: Both a lysine and a glutamate residue in the active site of tryptophan halogenase are essential for its chlorination activity. A mechanism for the regioselective enzymatic chlorination of tryptophan involving both amino acids is suggested (see scheme). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

AB - (Chemical Equation Presented) It takes two: Both a lysine and a glutamate residue in the active site of tryptophan halogenase are essential for its chlorination activity. A mechanism for the regioselective enzymatic chlorination of tryptophan involving both amino acids is suggested (see scheme). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

U2 - 10.1002/anie.200802466

DO - 10.1002/anie.200802466

M3 - Article

SN - 1521-3773

VL - 47

SP - 9533

EP - 9536

JO - Angewandte Chemie-International Edition

JF - Angewandte Chemie-International Edition

IS - 49

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