New insights into the plasticity of the endothelial phenotype

Lindsay S Cooley; Dylan R Edwards

doi:10.1042/BST20110723

New insights into the plasticity of the endothelial phenotype

Lindsay S Cooley, Dylan R Edwards

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The mammalian vascular system consists of two distinct, but closely related, networks: the blood vasculature (itself divided into arterial and venous networks) and the lymphatic vasculature. EC (endothelial cell) lineage specification has been proposed to be determined during embryonic development, after which the ECs are committed to their fate. However, increasing evidence suggests that ECs retain various degrees of plasticity, and have the ability to express characteristics of alternative cell lineages. Therapeutic control of endothelial plasticity will allow greater understanding of the genesis and treatment of several vascular diseases.

Original language	English
Pages (from-to)	1639-1643
Number of pages	5
Journal	Biochemical Society Transactions
Volume	39
Issue number	6
DOIs	https://doi.org/10.1042/BST20110723
Publication status	Published - Dec 2011

Keywords

Animals
Blood Vessels
Cell Lineage
Endothelial Cells
Humans
Lymphatic Vessels
Models, Biological
Phenotype

Access to Document

10.1042/BST20110723

Cite this

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abstract = "The mammalian vascular system consists of two distinct, but closely related, networks: the blood vasculature (itself divided into arterial and venous networks) and the lymphatic vasculature. EC (endothelial cell) lineage specification has been proposed to be determined during embryonic development, after which the ECs are committed to their fate. However, increasing evidence suggests that ECs retain various degrees of plasticity, and have the ability to express characteristics of alternative cell lineages. Therapeutic control of endothelial plasticity will allow greater understanding of the genesis and treatment of several vascular diseases.",

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AU - Edwards, Dylan R

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AB - The mammalian vascular system consists of two distinct, but closely related, networks: the blood vasculature (itself divided into arterial and venous networks) and the lymphatic vasculature. EC (endothelial cell) lineage specification has been proposed to be determined during embryonic development, after which the ECs are committed to their fate. However, increasing evidence suggests that ECs retain various degrees of plasticity, and have the ability to express characteristics of alternative cell lineages. Therapeutic control of endothelial plasticity will allow greater understanding of the genesis and treatment of several vascular diseases.

KW - Animals

KW - Blood Vessels

KW - Cell Lineage

KW - Endothelial Cells

KW - Humans

KW - Lymphatic Vessels

KW - Models, Biological

KW - Phenotype

U2 - 10.1042/BST20110723

DO - 10.1042/BST20110723

M3 - Article

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VL - 39

SP - 1639

EP - 1643

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 0300-5127

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ER -