New pacidamycins biosynthetically: probing N- and C-terminal substrate specificity of an unusual NRPS

Amany E. Ragab; Sabine Gruschow; Emma J. Rackham; Rebecca J. M. Goss

doi:10.1039/C003964K

New pacidamycins biosynthetically: probing N- and C-terminal substrate specificity of an unusual NRPS

Amany E. Ragab, Sabine Gruschow, Emma J. Rackham, Rebecca J. M. Goss

School of Chemistry

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Feeding phenylalanine analogues to Streptomyces coeruleorubidus reveals the remarkable steric and electronic flexibility of this biosynthetic pathway and leads to the generation of a series of new halopacidamycins.

Original language	English
Pages (from-to)	3128-3129
Number of pages	2
Journal	Organic & Biomolecular Chemistry
Volume	8
Issue number	14
DOIs	https://doi.org/10.1039/C003964K
Publication status	Published - 2010

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10.1039/C003964K

Cite this

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title = "New pacidamycins biosynthetically: probing N- and C-terminal substrate specificity of an unusual NRPS",

abstract = "Feeding phenylalanine analogues to Streptomyces coeruleorubidus reveals the remarkable steric and electronic flexibility of this biosynthetic pathway and leads to the generation of a series of new halopacidamycins.",

author = "Ragab, {Amany E.} and Sabine Gruschow and Rackham, {Emma J.} and Goss, {Rebecca J. M.}",

year = "2010",

doi = "10.1039/C003964K",

language = "English",

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pages = "3128--3129",

journal = "Organic & Biomolecular Chemistry",

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publisher = "Royal Society of Chemistry",

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AU - Ragab, Amany E.

AU - Gruschow, Sabine

AU - Rackham, Emma J.

AU - Goss, Rebecca J. M.

PY - 2010

Y1 - 2010

N2 - Feeding phenylalanine analogues to Streptomyces coeruleorubidus reveals the remarkable steric and electronic flexibility of this biosynthetic pathway and leads to the generation of a series of new halopacidamycins.

AB - Feeding phenylalanine analogues to Streptomyces coeruleorubidus reveals the remarkable steric and electronic flexibility of this biosynthetic pathway and leads to the generation of a series of new halopacidamycins.

U2 - 10.1039/C003964K

DO - 10.1039/C003964K

M3 - Article

VL - 8

SP - 3128

EP - 3129

JO - Organic & Biomolecular Chemistry

JF - Organic & Biomolecular Chemistry

SN - 1477-0520

IS - 14

ER -