Nitrate and nitrite in biology, nutrition and therapeutics

Jon O Lundberg; Mark T Gladwin; Amrita Ahluwalia; Nigel Benjamin; Nathan S Bryan; Anthony Butler; Pedro Cabrales; Angela Fago; Martin Feelisch; Peter C Ford; Bruce A Freeman; Michael Frenneaux; Joel Friedman; Malte Kelm; Christopher G Kevil; Daniel B Kim-Shapiro; Andrey V Kozlov; Jack R Lancaster; David J Lefer; Kenneth McColl; Kenneth McCurry; Rakesh P Patel; Joel Petersson; Tienush Rassaf; Valentin P Reutov; George B Richter-Addo; Alan Schechter; Sruti Shiva; Koichiro Tsuchiya; Ernst E van Faassen; Andrew J Webb; Brian S Zuckerbraun; Jay L Zweier; Eddie Weitzberg

doi:10.1038/nchembio.260

Nitrate and nitrite in biology, nutrition and therapeutics

Jon O Lundberg, Mark T Gladwin, Amrita Ahluwalia, Nigel Benjamin, Nathan S Bryan, Anthony Butler, Pedro Cabrales, Angela Fago, Martin Feelisch, Peter C Ford, Bruce A Freeman, Michael Frenneaux, Joel Friedman, Malte Kelm, Christopher G Kevil, Daniel B Kim-Shapiro, Andrey V Kozlov, Jack R Lancaster, David J Lefer, Kenneth McCollKenneth McCurry, Rakesh P Patel, Joel Petersson, Tienush Rassaf, Valentin P Reutov, George B Richter-Addo, Alan Schechter, Sruti Shiva, Koichiro Tsuchiya, Ernst E van Faassen, Andrew J Webb, Brian S Zuckerbraun, Jay L Zweier, Eddie Weitzberg

Research output: Contribution to journal › Article › peer-review

486 Citations (SciVal)

Abstract

Inorganic nitrate and nitrite from endogenous or dietary sources are metabolized in vivo to nitric oxide (NO) and other bioactive nitrogen oxides. The nitrate-nitrite-NO pathway is emerging as an important mediator of blood flow regulation, cell signaling, energetics and tissue responses to hypoxia. The latest advances in our understanding of the biochemistry, physiology and therapeutics of nitrate, nitrite and NO were discussed during a recent 2-day meeting at the Nobel Forum, Karolinska Institutet in Stockholm.

Original language	English
Pages (from-to)	865-869
Number of pages	5
Journal	Nature Chemical Biology
Volume	5
Issue number	12
DOIs	https://doi.org/10.1038/nchembio.260
Publication status	Published - Dec 2009

Keywords

Animals
Diet
Energy Metabolism
Humans
Mitochondria
Nitrates
Nitric Oxide
Nitrites
Signal Transduction

Access to Document

10.1038/nchembio.260

Cite this

Lundberg, J. O., Gladwin, M. T., Ahluwalia, A., Benjamin, N., Bryan, N. S., Butler, A., Cabrales, P., Fago, A., Feelisch, M., Ford, P. C., Freeman, B. A., Frenneaux, M., Friedman, J., Kelm, M., Kevil, C. G., Kim-Shapiro, D. B., Kozlov, A. V., Lancaster, J. R., Lefer, D. J., ... Weitzberg, E. (2009). Nitrate and nitrite in biology, nutrition and therapeutics. Nature Chemical Biology, 5(12), 865-869. https://doi.org/10.1038/nchembio.260

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abstract = "Inorganic nitrate and nitrite from endogenous or dietary sources are metabolized in vivo to nitric oxide (NO) and other bioactive nitrogen oxides. The nitrate-nitrite-NO pathway is emerging as an important mediator of blood flow regulation, cell signaling, energetics and tissue responses to hypoxia. The latest advances in our understanding of the biochemistry, physiology and therapeutics of nitrate, nitrite and NO were discussed during a recent 2-day meeting at the Nobel Forum, Karolinska Institutet in Stockholm.",

keywords = "Animals, Diet, Energy Metabolism, Humans, Mitochondria, Nitrates, Nitric Oxide, Nitrites, Signal Transduction",

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Lundberg, JO, Gladwin, MT, Ahluwalia, A, Benjamin, N, Bryan, NS, Butler, A, Cabrales, P, Fago, A, Feelisch, M, Ford, PC, Freeman, BA, Frenneaux, M, Friedman, J, Kelm, M, Kevil, CG, Kim-Shapiro, DB, Kozlov, AV, Lancaster, JR, Lefer, DJ, McColl, K, McCurry, K, Patel, RP, Petersson, J, Rassaf, T, Reutov, VP, Richter-Addo, GB, Schechter, A, Shiva, S, Tsuchiya, K, van Faassen, EE, Webb, AJ, Zuckerbraun, BS, Zweier, JL & Weitzberg, E 2009, 'Nitrate and nitrite in biology, nutrition and therapeutics', Nature Chemical Biology, vol. 5, no. 12, pp. 865-869. https://doi.org/10.1038/nchembio.260

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AU - Butler, Anthony

AU - Cabrales, Pedro

AU - Fago, Angela

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AU - Freeman, Bruce A

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AU - Friedman, Joel

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AU - Kim-Shapiro, Daniel B

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AU - Lefer, David J

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AU - McCurry, Kenneth

AU - Patel, Rakesh P

AU - Petersson, Joel

AU - Rassaf, Tienush

AU - Reutov, Valentin P

AU - Richter-Addo, George B

AU - Schechter, Alan

AU - Shiva, Sruti

AU - Tsuchiya, Koichiro

AU - van Faassen, Ernst E

AU - Webb, Andrew J

AU - Zuckerbraun, Brian S

AU - Zweier, Jay L

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KW - Animals

KW - Diet

KW - Energy Metabolism

KW - Humans

KW - Mitochondria

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KW - Nitric Oxide

KW - Nitrites

KW - Signal Transduction

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SN - 1552-4450

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