Nitrosative stress as a modulator of inflammatory change in a model of Takotsubo Syndrome

Sven Y. Surikow; Thanh H. Nguyen; Irene Stafford; Matthew Chapman; Sujith Chacko; Kuljit Singh; Giovanni Licari; Betty Raman; Darren J. Kelly; Yuan Zhang; Mark T. Waddingham; Doan T. Ngo; Alexander P. Bate; Su Jen Chua; Michael P. Frenneaux; John D. Horowitz

doi:10.1016/j.jacbts.2017.10.002

Nitrosative stress as a modulator of inflammatory change in a model of Takotsubo Syndrome

Sven Y. Surikow, Thanh H. Nguyen, Irene Stafford, Matthew Chapman, Sujith Chacko, Kuljit Singh, Giovanni Licari, Betty Raman, Darren J. Kelly, Yuan Zhang, Mark T. Waddingham, Doan T. Ngo, Alexander P. Bate, Su Jen Chua, Michael P. Frenneaux, John D. Horowitz

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Abstract

Previous studies have shown that patients with Takotsubo syndrome (TS) have supranormal nitric oxide signaling, and post-mortem studies of TS heart samples revealed nitrosative stress. Therefore, we first showed in a female rat model that isoproterenol induces TS-like echocardiographic changes, evidence of nitrosative stress, and consequent activation of the energy-depleting enzyme poly(ADP-ribose) polymerase-1. We subsequently showed that pre-treatment with an inhibitor of poly(ADP-ribose) polymerase-1 ameliorated contractile abnormalities. These findings thus add to previous reports of aberrant β-adrenoceptor signaling (coupled with nitric oxide synthase activation) to elucidate mechanisms of impaired cardiac function in TS and point to potential methods of treatment.

Original language	English
Pages (from-to)	213-226
Number of pages	14
Journal	JACC: Basic to Translational Science
Volume	3
Issue number	2
Early online date	18 Apr 2018
DOIs	https://doi.org/10.1016/j.jacbts.2017.10.002
Publication status	Published - Apr 2018

Keywords

Takotsubo cardiomyopathy
myocardial inflammation
oxidative stress
poly(ADP-Ribose) polymerase-1

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10.1016/j.jacbts.2017.10.002Licence: CC BY-NC-ND

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Cite this

Surikow, S. Y., Nguyen, T. H., Stafford, I., Chapman, M., Chacko, S., Singh, K., Licari, G., Raman, B., Kelly, D. J., Zhang, Y., Waddingham, M. T., Ngo, D. T., Bate, A. P., Chua, S. J., Frenneaux, M. P., & Horowitz, J. D. (2018). Nitrosative stress as a modulator of inflammatory change in a model of Takotsubo Syndrome. JACC: Basic to Translational Science, 3(2), 213-226. https://doi.org/10.1016/j.jacbts.2017.10.002

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title = "Nitrosative stress as a modulator of inflammatory change in a model of Takotsubo Syndrome",

abstract = "Previous studies have shown that patients with Takotsubo syndrome (TS) have supranormal nitric oxide signaling, and post-mortem studies of TS heart samples revealed nitrosative stress. Therefore, we first showed in a female rat model that isoproterenol induces TS-like echocardiographic changes, evidence of nitrosative stress, and consequent activation of the energy-depleting enzyme poly(ADP-ribose) polymerase-1. We subsequently showed that pre-treatment with an inhibitor of poly(ADP-ribose) polymerase-1 ameliorated contractile abnormalities. These findings thus add to previous reports of aberrant β-adrenoceptor signaling (coupled with nitric oxide synthase activation) to elucidate mechanisms of impaired cardiac function in TS and point to potential methods of treatment.",

keywords = "Takotsubo cardiomyopathy, myocardial inflammation, oxidative stress, poly(ADP-Ribose) polymerase-1",

author = "Surikow, {Sven Y.} and Nguyen, {Thanh H.} and Irene Stafford and Matthew Chapman and Sujith Chacko and Kuljit Singh and Giovanni Licari and Betty Raman and Kelly, {Darren J.} and Yuan Zhang and Waddingham, {Mark T.} and Ngo, {Doan T.} and Bate, {Alexander P.} and Chua, {Su Jen} and Frenneaux, {Michael P.} and Horowitz, {John D.}",

year = "2018",

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doi = "10.1016/j.jacbts.2017.10.002",

language = "English",

volume = "3",

pages = "213--226",

journal = "JACC: Basic to Translational Science",

issn = "2452-302X",

publisher = "Elsevier",

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Surikow, SY, Nguyen, TH, Stafford, I, Chapman, M, Chacko, S, Singh, K, Licari, G, Raman, B, Kelly, DJ, Zhang, Y, Waddingham, MT, Ngo, DT, Bate, AP, Chua, SJ, Frenneaux, MP & Horowitz, JD 2018, 'Nitrosative stress as a modulator of inflammatory change in a model of Takotsubo Syndrome', JACC: Basic to Translational Science, vol. 3, no. 2, pp. 213-226. https://doi.org/10.1016/j.jacbts.2017.10.002

TY - JOUR

T1 - Nitrosative stress as a modulator of inflammatory change in a model of Takotsubo Syndrome

AU - Surikow, Sven Y.

AU - Nguyen, Thanh H.

AU - Stafford, Irene

AU - Chapman, Matthew

AU - Chacko, Sujith

AU - Singh, Kuljit

AU - Licari, Giovanni

AU - Raman, Betty

AU - Kelly, Darren J.

AU - Zhang, Yuan

AU - Waddingham, Mark T.

AU - Ngo, Doan T.

AU - Bate, Alexander P.

AU - Chua, Su Jen

AU - Frenneaux, Michael P.

AU - Horowitz, John D.

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AB - Previous studies have shown that patients with Takotsubo syndrome (TS) have supranormal nitric oxide signaling, and post-mortem studies of TS heart samples revealed nitrosative stress. Therefore, we first showed in a female rat model that isoproterenol induces TS-like echocardiographic changes, evidence of nitrosative stress, and consequent activation of the energy-depleting enzyme poly(ADP-ribose) polymerase-1. We subsequently showed that pre-treatment with an inhibitor of poly(ADP-ribose) polymerase-1 ameliorated contractile abnormalities. These findings thus add to previous reports of aberrant β-adrenoceptor signaling (coupled with nitric oxide synthase activation) to elucidate mechanisms of impaired cardiac function in TS and point to potential methods of treatment.

KW - Takotsubo cardiomyopathy

KW - myocardial inflammation

KW - oxidative stress

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