TY - JOUR
T1 - No benefit of auditory closed-loop stimulation on memory for semantically-incongruent associations
AU - Harrington, Marcus O.
AU - Ngo, Hong-Viet V.
AU - Cairney, Scott A.
N1 - Funding Information: This work was supported by Medical Research Council (MRC) Career Development Award MR/P020208/1 to S.A.C.
PY - 2021/9
Y1 - 2021/9
N2 - Auditory closed-loop stimulation has gained traction in recent years as a means of enhancing slow oscillatory activity and, consequently, sleep-associated memory consolidation. Previous studies on this topic have primarily focused on the consolidation of semantically-congruent associations. In this study, we investigated the effect of auditory closed-loop stimulation on the overnight retention of semantically-incongruent associations. Twelve healthy males (age: M = 20.06, SD = 2.02 years) participated in two experimental conditions (simulation and sham). In the stimulation condition, clicks were delivered in phase with slow oscillation up-states, whereas in the sham condition no auditory stimuli were applied. Corroborating earlier work, stimulation (vs. sham) enhanced the slow oscillation rhythm, phase-coupled spindle activity and slow oscillation power. However, there was no benefit of stimulation on overnight memory retention. These findings suggest that closed-loop stimulation does not benefit semantically-incongruent associations.
AB - Auditory closed-loop stimulation has gained traction in recent years as a means of enhancing slow oscillatory activity and, consequently, sleep-associated memory consolidation. Previous studies on this topic have primarily focused on the consolidation of semantically-congruent associations. In this study, we investigated the effect of auditory closed-loop stimulation on the overnight retention of semantically-incongruent associations. Twelve healthy males (age: M = 20.06, SD = 2.02 years) participated in two experimental conditions (simulation and sham). In the stimulation condition, clicks were delivered in phase with slow oscillation up-states, whereas in the sham condition no auditory stimuli were applied. Corroborating earlier work, stimulation (vs. sham) enhanced the slow oscillation rhythm, phase-coupled spindle activity and slow oscillation power. However, there was no benefit of stimulation on overnight memory retention. These findings suggest that closed-loop stimulation does not benefit semantically-incongruent associations.
KW - Declarative memory
KW - Semantic memory
KW - Slow-wave sleep
UR - http://www.scopus.com/inward/record.url?scp=85108787984&partnerID=8YFLogxK
U2 - 10.1016/j.nlm.2021.107482
DO - 10.1016/j.nlm.2021.107482
M3 - Article
C2 - 34182134
AN - SCOPUS:85108787984
SN - 1074-7427
VL - 183
JO - Neurobiology of Learning and Memory
JF - Neurobiology of Learning and Memory
M1 - 107482
ER -