No consistent evidence of differential cardiovascular risk amongst proton-pump inhibitors when used with clopidogrel: meta-analysis

Chun Shing Kwok, Vinodh Jeevanantham, Buddhadeb Dawn, Yoon Kong Loke

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87 Citations (Scopus)


Data from pharmacokinetic and pharmacodynamic studies indicate that the adverse clopidogrel - proton pump inhibitor (PPI) interaction may vary between PPIs, with pantoprazole considered relatively less problematic. We aimed to evaluate systematically whether individual PPIs differ in their risk for cardiovascular events when concomitantly administered with clopidogrel.
Original languageEnglish
Pages (from-to)965-74
Number of pages10
JournalInternational Journal of Cardiology
Issue number3
Publication statusPublished - 10 Aug 2013

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