No evidence that the skeletal non-response to potassium alkali supplements in healthy postmenopausal women depends on blood pressure or sodium chloride intake

L. A. Frassetto, A. C. Hardcastle, A. Sebastian, L. Aucott, W. D. Fraser, D. M. Reid, H. M. Macdonald

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


In vitro studies demonstrate that bone is degraded in an acidic environment due to chemical reactions and through effects on bone cells. Clinical evidence is insufficient to unequivocally resolve whether the diet net acid or base load bone affects breakdown in humans. Increasing dietary salt (sodium chloride, NaCl) mildly increases blood acidity in humans and in rats with increased sensitivity to the blood pressure effects of salt, whereas increased potassium (K) intake can decrease blood pressure. Blood pressure responses to NaCl or K may potentially be a marker for increased bone turnover or lower bone mineral density (BMD) in women at higher risk for osteoporosis and fracture.
Original languageEnglish
Pages (from-to)1315-1322
Number of pages8
JournalEuropean Journal of Clinical Nutrition
Issue number12
Publication statusPublished - Dec 2012


  • Adult
  • Aged
  • Aged, 80 and over
  • Alkalies
  • Biological Markers
  • Blood Pressure
  • Bone Density
  • Bone Resorption
  • California
  • Chlorides
  • Diet
  • Dietary Supplements
  • Female
  • Humans
  • Middle Aged
  • Osteoporosis, Postmenopausal
  • Potassium, Dietary
  • Retrospective Studies
  • Scotland
  • Sodium
  • Sodium Chloride, Dietary
  • Spine

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