NO metabolite flux across the human coronary circulation

Stephen C Rogers, Afshin Khalatbari, Borunendra N Datta, Sue Ellery, Vince Paul, Michael P Frenneaux, Philip E James

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The theory of a red blood cell derived nitric oxide (NO) reserve conserving NO bioactivity and delivering NO as a function of oxygen demand has been the subject of much interest. We identified the human coronary circulation as an ideal model system in which to analyse NO metabolites because of its large physiological oxygen gradient. Our objective was to identify whether oxygen drove apportion between various NO metabolite species across a single vascular bed.
Original languageEnglish
Pages (from-to)434-41
Number of pages8
JournalCardiovascular Research
Volume75
Issue number2
DOIs
Publication statusPublished - 15 Jul 2007

Keywords

  • Adult
  • Analysis of Variance
  • Coronary Circulation
  • Endothelium, Vascular
  • Erythrocytes
  • Female
  • Hemoglobins
  • Humans
  • Luminescence
  • Male
  • Middle Aged
  • Nitrates
  • Nitric Oxide
  • Nitric Oxide Synthase
  • Nitrites
  • Oxygen
  • Pulmonary Artery
  • omega-N-Methylarginine

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