NO metabolite flux across the human coronary circulation

Stephen C Rogers; Afshin Khalatbari; Borunendra N Datta; Sue Ellery; Vince Paul; Michael P Frenneaux; Philip E James

doi:10.1016/j.cardiores.2007.04.019

NO metabolite flux across the human coronary circulation

Stephen C Rogers, Afshin Khalatbari, Borunendra N Datta, Sue Ellery, Vince Paul, Michael P Frenneaux, Philip E James

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

The theory of a red blood cell derived nitric oxide (NO) reserve conserving NO bioactivity and delivering NO as a function of oxygen demand has been the subject of much interest. We identified the human coronary circulation as an ideal model system in which to analyse NO metabolites because of its large physiological oxygen gradient. Our objective was to identify whether oxygen drove apportion between various NO metabolite species across a single vascular bed.

Original language	English
Pages (from-to)	434-41
Number of pages	8
Journal	Cardiovascular Research
Volume	75
Issue number	2
DOIs	https://doi.org/10.1016/j.cardiores.2007.04.019
Publication status	Published - 15 Jul 2007

Keywords

Adult
Analysis of Variance
Coronary Circulation
Endothelium, Vascular
Erythrocytes
Female
Hemoglobins
Humans
Luminescence
Male
Middle Aged
Nitrates
Nitric Oxide
Nitric Oxide Synthase
Nitrites
Oxygen
Pulmonary Artery
omega-N-Methylarginine

Access to Document

10.1016/j.cardiores.2007.04.019

Cite this

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title = "NO metabolite flux across the human coronary circulation",

abstract = "The theory of a red blood cell derived nitric oxide (NO) reserve conserving NO bioactivity and delivering NO as a function of oxygen demand has been the subject of much interest. We identified the human coronary circulation as an ideal model system in which to analyse NO metabolites because of its large physiological oxygen gradient. Our objective was to identify whether oxygen drove apportion between various NO metabolite species across a single vascular bed.",

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AU - Rogers, Stephen C

AU - Khalatbari, Afshin

AU - Datta, Borunendra N

AU - Ellery, Sue

AU - Paul, Vince

AU - Frenneaux, Michael P

AU - James, Philip E

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AB - The theory of a red blood cell derived nitric oxide (NO) reserve conserving NO bioactivity and delivering NO as a function of oxygen demand has been the subject of much interest. We identified the human coronary circulation as an ideal model system in which to analyse NO metabolites because of its large physiological oxygen gradient. Our objective was to identify whether oxygen drove apportion between various NO metabolite species across a single vascular bed.

KW - Adult

KW - Analysis of Variance

KW - Coronary Circulation

KW - Endothelium, Vascular

KW - Erythrocytes

KW - Female

KW - Hemoglobins

KW - Humans

KW - Luminescence

KW - Male

KW - Middle Aged

KW - Nitrates

KW - Nitric Oxide

KW - Nitric Oxide Synthase

KW - Nitrites

KW - Oxygen

KW - Pulmonary Artery

KW - omega-N-Methylarginine

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SN - 0008-6363

VL - 75

SP - 434

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JF - Cardiovascular Research

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