Noninvasive techniques for tracking biological aging of the cardiovascular system: JACC Family Series

Zahra Raisi-Estabragh, Liliana Szabo, Art Schuermans, Ahmed M. Salih, Calvin W. L. Chin, Hajnalka Vágó, Andre Altmann, Fu Siong Ng, Pankaj Garg, Sofia Pavanello, Thomas H. Marwick, Steffen E. Petersen

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Population aging is one of the most important demographic transformations of our time. Increasing the “health span”—the proportion of life spent in good health—is a global priority. Biological aging comprises molecular and cellular modifications over many years, which culminate in gradual physiological decline across multiple organ systems and predispose to age-related illnesses. Cardiovascular disease is a major cause of ill health and premature death in older people. The rate at which biological aging occurs varies across individuals of the same age and is influenced by a wide range of genetic and environmental exposures. The authors review the hallmarks of biological cardiovascular aging and their capture using imaging and other noninvasive techniques and examine how this information may be used to understand aging trajectories, with the aim of guiding individual- and population-level interventions to promote healthy aging.
Original languageEnglish
Pages (from-to)533-551
Number of pages19
JournalJACC: Cardiovascular Imaging
Issue number5
Early online date8 Apr 2024
Publication statusPublished - May 2024


  • biological heart age
  • cardiac computed tomography
  • cardiac magnetic resonance
  • echocardiography
  • healthy aging
  • molecular markers
  • multimodality cardiovascular imaging

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