Nor-ursodeoxycholic acid reverses hepatocyte-specific nemo-dependent steatohepatitis

Naiara Beraza, Lisa Ofner-Ziegenfuss, Haksier Ehedego, Mark Boekschoten, Stephan C Bischoff, Michael Muller, Michael Trauner, Christian Trautwein

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Hepatocyte-specific NEMO/NF-κB deleted mice (NEMO(Δhepa)) develop spontaneous non-alcoholic steatohepatitis (NASH). Free fatty acids and bile acids promote DR5 expression. TRAIL/NK cell-mediated activation of TRAIL-R2/DR5 plays an important role during acute injury in NEMO(Δhepa) mice.
Original languageEnglish
Pages (from-to)387-396
Number of pages10
JournalGut
Volume60
Issue number3
DOIs
Publication statusPublished - Mar 2011

Keywords

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal
  • Apoptosis
  • Cell Proliferation
  • Diet, Fat-Restricted
  • Disease Progression
  • Down-Regulation
  • Drug Evaluation, Preclinical
  • Fatty Liver
  • Hepatocytes
  • Intracellular Signaling Peptides and Proteins
  • Lipids
  • Liver
  • Liver Cirrhosis
  • Mice
  • Mice, Knockout
  • Oligonucleotide Array Sequence Analysis
  • Ursodeoxycholic Acid

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