Abstract
Hepatocyte-specific NEMO/NF-κB deleted mice (NEMO(Δhepa)) develop spontaneous non-alcoholic steatohepatitis (NASH). Free fatty acids and bile acids promote DR5 expression. TRAIL/NK cell-mediated activation of TRAIL-R2/DR5 plays an important role during acute injury in NEMO(Δhepa) mice.
Original language | English |
---|---|
Pages (from-to) | 387-396 |
Number of pages | 10 |
Journal | Gut |
Volume | 60 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2011 |
Keywords
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
- Apoptosis
- Cell Proliferation
- Diet, Fat-Restricted
- Disease Progression
- Down-Regulation
- Drug Evaluation, Preclinical
- Fatty Liver
- Hepatocytes
- Intracellular Signaling Peptides and Proteins
- Lipids
- Liver
- Liver Cirrhosis
- Mice
- Mice, Knockout
- Oligonucleotide Array Sequence Analysis
- Ursodeoxycholic Acid