Nor-ursodeoxycholic acid reverses hepatocyte-specific nemo-dependent steatohepatitis

Naiara Beraza; Lisa Ofner-Ziegenfuss; Haksier Ehedego; Mark Boekschoten; Stephan C Bischoff; Michael Muller; Michael Trauner; Christian Trautwein

doi:10.1136/gut.2010.223834

Nor-ursodeoxycholic acid reverses hepatocyte-specific nemo-dependent steatohepatitis

Naiara Beraza, Lisa Ofner-Ziegenfuss, Haksier Ehedego, Mark Boekschoten, Stephan C Bischoff, Michael Muller, Michael Trauner, Christian Trautwein

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Hepatocyte-specific NEMO/NF-κB deleted mice (NEMO(Δhepa)) develop spontaneous non-alcoholic steatohepatitis (NASH). Free fatty acids and bile acids promote DR5 expression. TRAIL/NK cell-mediated activation of TRAIL-R2/DR5 plays an important role during acute injury in NEMO(Δhepa) mice.

Original language	English
Pages (from-to)	387-396
Number of pages	10
Journal	Gut
Volume	60
Issue number	3
DOIs	https://doi.org/10.1136/gut.2010.223834
Publication status	Published - Mar 2011

Keywords

Animals
Anti-Inflammatory Agents, Non-Steroidal
Apoptosis
Cell Proliferation
Diet, Fat-Restricted
Disease Progression
Down-Regulation
Drug Evaluation, Preclinical
Fatty Liver
Hepatocytes
Intracellular Signaling Peptides and Proteins
Lipids
Liver
Liver Cirrhosis
Mice
Mice, Knockout
Oligonucleotide Array Sequence Analysis
Ursodeoxycholic Acid

Access to Document

10.1136/gut.2010.223834

Cite this

@article{833cb511771c43a49e99c94688091fd4,

title = "Nor-ursodeoxycholic acid reverses hepatocyte-specific nemo-dependent steatohepatitis",

abstract = "Hepatocyte-specific NEMO/NF-κB deleted mice (NEMO(Δhepa)) develop spontaneous non-alcoholic steatohepatitis (NASH). Free fatty acids and bile acids promote DR5 expression. TRAIL/NK cell-mediated activation of TRAIL-R2/DR5 plays an important role during acute injury in NEMO(Δhepa) mice.",

keywords = "Animals, Anti-Inflammatory Agents, Non-Steroidal, Apoptosis, Cell Proliferation, Diet, Fat-Restricted, Disease Progression, Down-Regulation, Drug Evaluation, Preclinical, Fatty Liver, Hepatocytes, Intracellular Signaling Peptides and Proteins, Lipids, Liver, Liver Cirrhosis, Mice, Mice, Knockout, Oligonucleotide Array Sequence Analysis, Ursodeoxycholic Acid",

author = "Naiara Beraza and Lisa Ofner-Ziegenfuss and Haksier Ehedego and Mark Boekschoten and Bischoff, {Stephan C} and Michael Muller and Michael Trauner and Christian Trautwein",

year = "2011",

month = mar,

doi = "10.1136/gut.2010.223834",

language = "English",

volume = "60",

pages = "387--396",

journal = "Gut",

issn = "0017-5749",

publisher = "BMJ Publishing Group",

number = "3",

}

TY - JOUR

T1 - Nor-ursodeoxycholic acid reverses hepatocyte-specific nemo-dependent steatohepatitis

AU - Beraza, Naiara

AU - Ofner-Ziegenfuss, Lisa

AU - Ehedego, Haksier

AU - Boekschoten, Mark

AU - Bischoff, Stephan C

AU - Muller, Michael

AU - Trauner, Michael

AU - Trautwein, Christian

PY - 2011/3

Y1 - 2011/3

N2 - Hepatocyte-specific NEMO/NF-κB deleted mice (NEMO(Δhepa)) develop spontaneous non-alcoholic steatohepatitis (NASH). Free fatty acids and bile acids promote DR5 expression. TRAIL/NK cell-mediated activation of TRAIL-R2/DR5 plays an important role during acute injury in NEMO(Δhepa) mice.

AB - Hepatocyte-specific NEMO/NF-κB deleted mice (NEMO(Δhepa)) develop spontaneous non-alcoholic steatohepatitis (NASH). Free fatty acids and bile acids promote DR5 expression. TRAIL/NK cell-mediated activation of TRAIL-R2/DR5 plays an important role during acute injury in NEMO(Δhepa) mice.

KW - Animals

KW - Anti-Inflammatory Agents, Non-Steroidal

KW - Apoptosis

KW - Cell Proliferation

KW - Diet, Fat-Restricted

KW - Disease Progression

KW - Down-Regulation

KW - Drug Evaluation, Preclinical

KW - Fatty Liver

KW - Hepatocytes

KW - Intracellular Signaling Peptides and Proteins

KW - Lipids

KW - Liver

KW - Liver Cirrhosis

KW - Mice

KW - Mice, Knockout

KW - Oligonucleotide Array Sequence Analysis

KW - Ursodeoxycholic Acid

U2 - 10.1136/gut.2010.223834

DO - 10.1136/gut.2010.223834

M3 - Article

C2 - 21115542

SN - 0017-5749

VL - 60

SP - 387

EP - 396

JO - Gut

JF - Gut

IS - 3

ER -