Norlignans, acylphloroglucinols, and a dimeric xanthone from Hypericum chinense

Wei Wang, Yi Han Zeng, Khadijo Osman, Kamlesh Shinde, Mukhlesur Rahman, Simon Gibbons, Qing Mu

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Abstract

Two new norlignans, hyperiones A (1) and B (2), three new acylphloroglucinols, aspidinol C (3) and hyperaspidinols A (5) and B (6), the known compound aspidinol D (4), and the symmetrical dimeric xanthone hyperidixanthone (7) were isolated from Hypericum chinense. Their structures were established by spectroscopic analysis. In an antibacterial assay using a panel of multidrug-resistant (MDR) strains, compounds 3 and 4 exhibited promising activity against the NorA efflux protein overexpressing MDR Staphylococcus aureus strain SA-1199B with a minimum inhibitory concentration (MIC) of 2 ?g/mL (8.4 ?M) and 4 ?g/mL (16.8 ?M), respectively. The positive control antibiotic norfloxacin showed activity at MIC 32 ?g/mL (100 ?M).
Original languageEnglish
Pages (from-to)1815-1820
Number of pages6
JournalJournal of Natural Products
Volume73
Issue number11
Early online date2 Nov 2010
DOIs
Publication statusPublished - 29 Nov 2010

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