Norlignans, acylphloroglucinols, and a dimeric xanthone from Hypericum chinense

Wei Wang; Yi Han Zeng; Khadijo Osman; Kamlesh Shinde; Mukhlesur Rahman; Simon Gibbons; Qing Mu

doi:10.1021/np1004483

Norlignans, acylphloroglucinols, and a dimeric xanthone from Hypericum chinense

Wei Wang, Yi Han Zeng, Khadijo Osman, Kamlesh Shinde, Mukhlesur Rahman, Simon Gibbons, Qing Mu

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

Two new norlignans, hyperiones A (1) and B (2), three new acylphloroglucinols, aspidinol C (3) and hyperaspidinols A (5) and B (6), the known compound aspidinol D (4), and the symmetrical dimeric xanthone hyperidixanthone (7) were isolated from Hypericum chinense. Their structures were established by spectroscopic analysis. In an antibacterial assay using a panel of multidrug-resistant (MDR) strains, compounds 3 and 4 exhibited promising activity against the NorA efflux protein overexpressing MDR Staphylococcus aureus strain SA-1199B with a minimum inhibitory concentration (MIC) of 2 ?g/mL (8.4 ?M) and 4 ?g/mL (16.8 ?M), respectively. The positive control antibiotic norfloxacin showed activity at MIC 32 ?g/mL (100 ?M).

Original language	English
Pages (from-to)	1815-1820
Number of pages	6
Journal	Journal of Natural Products
Volume	73
Issue number	11
Early online date	2 Nov 2010
DOIs	https://doi.org/10.1021/np1004483
Publication status	Published - 29 Nov 2010

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10.1021/np1004483

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title = "Norlignans, acylphloroglucinols, and a dimeric xanthone from Hypericum chinense",

abstract = "Two new norlignans, hyperiones A (1) and B (2), three new acylphloroglucinols, aspidinol C (3) and hyperaspidinols A (5) and B (6), the known compound aspidinol D (4), and the symmetrical dimeric xanthone hyperidixanthone (7) were isolated from Hypericum chinense. Their structures were established by spectroscopic analysis. In an antibacterial assay using a panel of multidrug-resistant (MDR) strains, compounds 3 and 4 exhibited promising activity against the NorA efflux protein overexpressing MDR Staphylococcus aureus strain SA-1199B with a minimum inhibitory concentration (MIC) of 2 ?g/mL (8.4 ?M) and 4 ?g/mL (16.8 ?M), respectively. The positive control antibiotic norfloxacin showed activity at MIC 32 ?g/mL (100 ?M).",

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T1 - Norlignans, acylphloroglucinols, and a dimeric xanthone from Hypericum chinense

AU - Wang, Wei

AU - Zeng, Yi Han

AU - Osman, Khadijo

AU - Shinde, Kamlesh

AU - Rahman, Mukhlesur

AU - Gibbons, Simon

AU - Mu, Qing

PY - 2010/11/29

Y1 - 2010/11/29

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AB - Two new norlignans, hyperiones A (1) and B (2), three new acylphloroglucinols, aspidinol C (3) and hyperaspidinols A (5) and B (6), the known compound aspidinol D (4), and the symmetrical dimeric xanthone hyperidixanthone (7) were isolated from Hypericum chinense. Their structures were established by spectroscopic analysis. In an antibacterial assay using a panel of multidrug-resistant (MDR) strains, compounds 3 and 4 exhibited promising activity against the NorA efflux protein overexpressing MDR Staphylococcus aureus strain SA-1199B with a minimum inhibitory concentration (MIC) of 2 ?g/mL (8.4 ?M) and 4 ?g/mL (16.8 ?M), respectively. The positive control antibiotic norfloxacin showed activity at MIC 32 ?g/mL (100 ?M).

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