Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects

Frances M K Williams, Aruna T Bansal, Joyce B van Meurs, Jordana T Bell, Ingrid Meulenbelt, Pradeep Suri, Fernando Rivadeneira, Philip N Sambrook, Albert Hofman, Sita Bierma-Zeinstra, Cristina Menni, Margreet Kloppenburg, P Eline Slagboom, David J Hunter, Alex J MacGregor, Andre G Uitterlinden, Tim D Spector, Alexander Macgregor

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79 Citations (Scopus)

Abstract

Lumbar disc degeneration (LDD) is an important cause of low back pain, which is a common and costly problem. LDD is characterised by disc space narrowing and osteophyte growth at the circumference of the disc. To date, the agnostic search of the genome by genome-wide association (GWA) to identify common variants associated with LDD has not been fruitful. This study is the first GWA meta-analysis of LDD.
Original languageEnglish
Pages (from-to)1141-8
Number of pages8
JournalAnnals of the Rheumatic Diseases
Volume72
Issue number7
DOIs
Publication statusPublished - Jul 2013

Keywords

  • Adult
  • Aged
  • CpG Islands
  • DNA Methylation
  • European Continental Ancestry Group
  • Female
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Humans
  • Intervertebral Disc Degeneration
  • Lumbar Vertebrae
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Ubiquitin-Protein Ligases

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