Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects

Frances M K Williams; Aruna T Bansal; Joyce B van Meurs; Jordana T Bell; Ingrid Meulenbelt; Pradeep Suri; Fernando Rivadeneira; Philip N Sambrook; Albert Hofman; Sita Bierma-Zeinstra; Cristina Menni; Margreet Kloppenburg; P Eline Slagboom; David J Hunter; Alex J MacGregor; Andre G Uitterlinden; Tim D Spector; Alexander Macgregor

doi:10.1136/annrheumdis-2012-201551

Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects

Frances M K Williams, Aruna T Bansal, Joyce B van Meurs, Jordana T Bell, Ingrid Meulenbelt, Pradeep Suri, Fernando Rivadeneira, Philip N Sambrook, Albert Hofman, Sita Bierma-Zeinstra, Cristina Menni, Margreet Kloppenburg, P Eline Slagboom, David J Hunter, Alex J MacGregor, Andre G Uitterlinden, Tim D Spector, Alexander Macgregor

Research output: Contribution to journal › Article › peer-review

96 Citations (Scopus)

Abstract

Lumbar disc degeneration (LDD) is an important cause of low back pain, which is a common and costly problem. LDD is characterised by disc space narrowing and osteophyte growth at the circumference of the disc. To date, the agnostic search of the genome by genome-wide association (GWA) to identify common variants associated with LDD has not been fruitful. This study is the first GWA meta-analysis of LDD.

Original language	English
Pages (from-to)	1141-8
Number of pages	8
Journal	Annals of the Rheumatic Diseases
Volume	72
Issue number	7
DOIs	https://doi.org/10.1136/annrheumdis-2012-201551
Publication status	Published - Jul 2013

Keywords

Adult
Aged
CpG Islands
DNA Methylation
European Continental Ancestry Group
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Intervertebral Disc Degeneration
Lumbar Vertebrae
Male
Middle Aged
Polymorphism, Single Nucleotide
Ubiquitin-Protein Ligases

Access to Document

10.1136/annrheumdis-2012-201551

Cite this

Williams, F. M. K., Bansal, A. T., van Meurs, J. B., Bell, J. T., Meulenbelt, I., Suri, P., Rivadeneira, F., Sambrook, P. N., Hofman, A., Bierma-Zeinstra, S., Menni, C., Kloppenburg, M., Slagboom, P. E., Hunter, D. J., MacGregor, A. J., Uitterlinden, A. G., Spector, T. D., & Macgregor, A. (2013). Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects. Annals of the Rheumatic Diseases, 72(7), 1141-8. https://doi.org/10.1136/annrheumdis-2012-201551

@article{49aed46526584a539adf06c39d0e6a5e,

title = "Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects",

abstract = "Lumbar disc degeneration (LDD) is an important cause of low back pain, which is a common and costly problem. LDD is characterised by disc space narrowing and osteophyte growth at the circumference of the disc. To date, the agnostic search of the genome by genome-wide association (GWA) to identify common variants associated with LDD has not been fruitful. This study is the first GWA meta-analysis of LDD.",

keywords = "Adult, Aged, CpG Islands, DNA Methylation, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Intervertebral Disc Degeneration, Lumbar Vertebrae, Male, Middle Aged, Polymorphism, Single Nucleotide, Ubiquitin-Protein Ligases",

author = "Williams, {Frances M K} and Bansal, {Aruna T} and {van Meurs}, {Joyce B} and Bell, {Jordana T} and Ingrid Meulenbelt and Pradeep Suri and Fernando Rivadeneira and Sambrook, {Philip N} and Albert Hofman and Sita Bierma-Zeinstra and Cristina Menni and Margreet Kloppenburg and Slagboom, {P Eline} and Hunter, {David J} and MacGregor, {Alex J} and Uitterlinden, {Andre G} and Spector, {Tim D} and Alexander Macgregor",

year = "2013",

month = jul,

doi = "10.1136/annrheumdis-2012-201551",

language = "English",

volume = "72",

pages = "1141--8",

journal = "Annals of the Rheumatic Diseases",

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Williams, FMK, Bansal, AT, van Meurs, JB, Bell, JT, Meulenbelt, I, Suri, P, Rivadeneira, F, Sambrook, PN, Hofman, A, Bierma-Zeinstra, S, Menni, C, Kloppenburg, M, Slagboom, PE, Hunter, DJ, MacGregor, AJ, Uitterlinden, AG, Spector, TD & Macgregor, A 2013, 'Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects', Annals of the Rheumatic Diseases, vol. 72, no. 7, pp. 1141-8. https://doi.org/10.1136/annrheumdis-2012-201551

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T1 - Novel genetic variants associated with lumbar disc degeneration in northern Europeans

T2 - a meta-analysis of 4600 subjects

AU - Williams, Frances M K

AU - Bansal, Aruna T

AU - van Meurs, Joyce B

AU - Bell, Jordana T

AU - Meulenbelt, Ingrid

AU - Suri, Pradeep

AU - Rivadeneira, Fernando

AU - Sambrook, Philip N

AU - Hofman, Albert

AU - Bierma-Zeinstra, Sita

AU - Menni, Cristina

AU - Kloppenburg, Margreet

AU - Slagboom, P Eline

AU - Hunter, David J

AU - MacGregor, Alex J

AU - Uitterlinden, Andre G

AU - Spector, Tim D

AU - Macgregor, Alexander

PY - 2013/7

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AB - Lumbar disc degeneration (LDD) is an important cause of low back pain, which is a common and costly problem. LDD is characterised by disc space narrowing and osteophyte growth at the circumference of the disc. To date, the agnostic search of the genome by genome-wide association (GWA) to identify common variants associated with LDD has not been fruitful. This study is the first GWA meta-analysis of LDD.

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KW - Aged

KW - CpG Islands

KW - DNA Methylation

KW - European Continental Ancestry Group

KW - Female

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Humans

KW - Intervertebral Disc Degeneration

KW - Lumbar Vertebrae

KW - Male

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Ubiquitin-Protein Ligases

U2 - 10.1136/annrheumdis-2012-201551

DO - 10.1136/annrheumdis-2012-201551

M3 - Article

C2 - 22993228

VL - 72

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JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

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ER -