Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics

Angela J. Wright, Sarah E. Matthews, Wolfgang B. Fischer, Paul D. Beer

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72 Citations (Scopus)

Abstract

A series of novel resorcin[4]arenes with extended it systems have been synthesised and developed as potassium-selective transporters. Resorcin[4]arenes that feature crown ether moieties function as efficient carriers of K+ across bulk liquid membranes showing enhanced selectivity over the other alkali metal ions relative to a model system (benzo[15]crown-5). Incorporation of functionalities suitable for pore formation, in addition to an extra annulus of aromatic residues, gives molecules which have remarkable ion-channel-mimicking behaviour in a biological lipid bilayer with outstanding K+/Na+ selectivity.
Original languageEnglish
Pages (from-to)3474-3481
Number of pages8
JournalChemistry - A European Journal
Volume7
Issue number16
DOIs
Publication statusPublished - 2001

Keywords

  • CALIX<4>ARENES
  • ionophores
  • BILAYERS
  • MEMBRANES
  • HOST MOLECULES
  • ion channels
  • planar lipid bilayer
  • alkali metals
  • BIND BIPYRIDINIUM
  • BENZO CROWN-ETHER
  • resorcin[4]arenes
  • GRAMICIDIN

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