Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics

Angela J. Wright, Sarah E. Matthews, Wolfgang B. Fischer, Paul D. Beer

    Research output: Contribution to journalArticlepeer-review

    76 Citations (Scopus)

    Abstract

    A series of novel resorcin[4]arenes with extended it systems have been synthesised and developed as potassium-selective transporters. Resorcin[4]arenes that feature crown ether moieties function as efficient carriers of K+ across bulk liquid membranes showing enhanced selectivity over the other alkali metal ions relative to a model system (benzo[15]crown-5). Incorporation of functionalities suitable for pore formation, in addition to an extra annulus of aromatic residues, gives molecules which have remarkable ion-channel-mimicking behaviour in a biological lipid bilayer with outstanding K+/Na+ selectivity.
    Original languageEnglish
    Pages (from-to)3474-3481
    Number of pages8
    JournalChemistry - A European Journal
    Volume7
    Issue number16
    DOIs
    Publication statusPublished - 2001

    Keywords

    • CALIX<4>ARENES
    • ionophores
    • BILAYERS
    • MEMBRANES
    • HOST MOLECULES
    • ion channels
    • planar lipid bilayer
    • alkali metals
    • BIND BIPYRIDINIUM
    • BENZO CROWN-ETHER
    • resorcin[4]arenes
    • GRAMICIDIN

    Cite this