TY - JOUR
T1 - Nucleotide second messengers in bacterial decision making
AU - Thompson, Catriona
AU - Malone, Jacob
PY - 2020/6
Y1 - 2020/6
N2 - Since the initial discovery of bacterial nucleotide second messengers (NSMs), we have made huge progress towards understanding these complex signalling networks. Many NSM networks contain dozens of metabolic enzymes and binding targets, whose activity is tightly controlled at every regulatory level. They function as global regulators and in specific signalling circuits, controlling multiple aspects of bacterial behaviour and development. Despite these advances there is much still to discover, with current research focussing on the molecular mechanisms of signalling circuits, the role of the environment in controlling NSM pathways and attempts to understand signalling at the whole cell/community level. Here we examine recent developments in the NSM signalling field and discuss their implications for understanding this important driver of microbial behaviour.
AB - Since the initial discovery of bacterial nucleotide second messengers (NSMs), we have made huge progress towards understanding these complex signalling networks. Many NSM networks contain dozens of metabolic enzymes and binding targets, whose activity is tightly controlled at every regulatory level. They function as global regulators and in specific signalling circuits, controlling multiple aspects of bacterial behaviour and development. Despite these advances there is much still to discover, with current research focussing on the molecular mechanisms of signalling circuits, the role of the environment in controlling NSM pathways and attempts to understand signalling at the whole cell/community level. Here we examine recent developments in the NSM signalling field and discuss their implications for understanding this important driver of microbial behaviour.
UR - http://www.scopus.com/inward/record.url?scp=85081278989&partnerID=8YFLogxK
U2 - 10.1016/j.mib.2020.02.006
DO - 10.1016/j.mib.2020.02.006
M3 - Article
VL - 55
SP - 34
EP - 39
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
SN - 1369-5274
ER -