Nutrition and genes in the development of orofacial clefting

Ingrid P. Krapels; Christl Vermeij-Keers; Michael Müller; Annelies de Klein; Régine P. Steegers-Theunissen

doi:10.1111/j.1753-4887.2006.tb00211.x

Nutrition and genes in the development of orofacial clefting

Ingrid P. Krapels, Christl Vermeij-Keers, Michael Müller, Annelies de Klein, Régine P. Steegers-Theunissen

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Clefts of the lip, alveolus, and/or palate, which are called orofacial clefts (OFC), occur in 0.5 to 3 per 1000 live and stillbirths. The pathogenesis of these congenital malformations remains largely unknown, but evidence is increasing that both nutritional and genetic factors are involved. Unlike genetic factors, nutritional causes can be corrected and may therefore contribute to the prevention of OFC. The goal of this review is to summarize the embryogenesis and genes involved in OFC, and to give an overview of the nutrients and related genes in humans. Improving our knowledge of the role of nutrition, genes, and their interactions in the pathogenesis of OFC may stimulate the development of nutritional interventions for OFC prevention in the future.

Original language	English
Pages (from-to)	280-288
Number of pages	9
Journal	Nutrition Reviews
Volume	64
Issue number	6
DOIs	https://doi.org/10.1111/j.1753-4887.2006.tb00211.x
Publication status	Published - Jun 2006

Keywords

Adult
Cleft Lip
Cleft Palate
Female
Genetic Predisposition to Disease
Humans
Maternal Nutritional Physiological Phenomena
Pregnancy
Risk Factors

Access to Document

10.1111/j.1753-4887.2006.tb00211.x

Cite this

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title = "Nutrition and genes in the development of orofacial clefting",

abstract = "Clefts of the lip, alveolus, and/or palate, which are called orofacial clefts (OFC), occur in 0.5 to 3 per 1000 live and stillbirths. The pathogenesis of these congenital malformations remains largely unknown, but evidence is increasing that both nutritional and genetic factors are involved. Unlike genetic factors, nutritional causes can be corrected and may therefore contribute to the prevention of OFC. The goal of this review is to summarize the embryogenesis and genes involved in OFC, and to give an overview of the nutrients and related genes in humans. Improving our knowledge of the role of nutrition, genes, and their interactions in the pathogenesis of OFC may stimulate the development of nutritional interventions for OFC prevention in the future.",

keywords = "Adult, Cleft Lip, Cleft Palate, Female, Genetic Predisposition to Disease, Humans, Maternal Nutritional Physiological Phenomena, Pregnancy, Risk Factors",

author = "Krapels, {Ingrid P.} and Christl Vermeij-Keers and Michael M{\"u}ller and {de Klein}, Annelies and Steegers-Theunissen, {R{\'e}gine P.}",

year = "2006",

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T1 - Nutrition and genes in the development of orofacial clefting

AU - Krapels, Ingrid P.

AU - Vermeij-Keers, Christl

AU - Müller, Michael

AU - de Klein, Annelies

AU - Steegers-Theunissen, Régine P.

PY - 2006/6

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N2 - Clefts of the lip, alveolus, and/or palate, which are called orofacial clefts (OFC), occur in 0.5 to 3 per 1000 live and stillbirths. The pathogenesis of these congenital malformations remains largely unknown, but evidence is increasing that both nutritional and genetic factors are involved. Unlike genetic factors, nutritional causes can be corrected and may therefore contribute to the prevention of OFC. The goal of this review is to summarize the embryogenesis and genes involved in OFC, and to give an overview of the nutrients and related genes in humans. Improving our knowledge of the role of nutrition, genes, and their interactions in the pathogenesis of OFC may stimulate the development of nutritional interventions for OFC prevention in the future.

AB - Clefts of the lip, alveolus, and/or palate, which are called orofacial clefts (OFC), occur in 0.5 to 3 per 1000 live and stillbirths. The pathogenesis of these congenital malformations remains largely unknown, but evidence is increasing that both nutritional and genetic factors are involved. Unlike genetic factors, nutritional causes can be corrected and may therefore contribute to the prevention of OFC. The goal of this review is to summarize the embryogenesis and genes involved in OFC, and to give an overview of the nutrients and related genes in humans. Improving our knowledge of the role of nutrition, genes, and their interactions in the pathogenesis of OFC may stimulate the development of nutritional interventions for OFC prevention in the future.

KW - Adult

KW - Cleft Lip

KW - Cleft Palate

KW - Female

KW - Genetic Predisposition to Disease

KW - Humans

KW - Maternal Nutritional Physiological Phenomena

KW - Pregnancy

KW - Risk Factors

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DO - 10.1111/j.1753-4887.2006.tb00211.x

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