Nutrition, diet and immunosenescence

Mònica Maijó, Sarah J. Clements, Kamal Ivory, Claudio Nicoletti, Simon Carding

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Abstract

Ageing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease. This complex process affects both the innate and adaptive immune systems with a progressive decline in most immune cell populations and defects in activation resulting in loss of function. Although host genetics and environmental factors, such as stress, exercise and diet can impact on the onset or course of immunosenescence, the mechanisms involved are largely unknown. This review focusses on identifying the most significant aspects of immunosenescence and on the evidence that nutritional intervention might delay this process, and consequently improve the quality of life of the elderly.
Original languageEnglish
Pages (from-to)116-128
Number of pages13
JournalMechanisms of Ageing and Development
Volume136-137
DOIs
Publication statusPublished - Mar 2014

Keywords

  • immunosenescence
  • ageing
  • nutrition

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