Ochronosis as an unusual cause of a valvular defect: a case report

Andreas Wilke, Dietmar Steverding

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Abstract

INTRODUCTION: Alkaptonuria (also known as ochronosis) is a genetic disorder characterised by the accumulation of homogentisic acid deposits in connective tissue. In rare cases, ochronosis can cause valvular heart disease. CASE PRESENTATION: We present the case of a 68-year-old Caucasian man with alkaptonuria-associated degenerative valvular defects with aortic, mitral and tricuspid valve insufficiency. The patient did not have any cardiac complaints and was referred to our clinic for evaluation of a conspicuous new heart murmur. CONCLUSION: This case report shows that early diagnosis of cardiovascular ochronosis gives us the opportunity to use conservative treatment to slow down the progression of valvular dysfunction.
Original languageEnglish
Article number9302
Number of pages5
JournalJournal of Medical Case Reports
Volume3
DOIs
Publication statusPublished - 2009

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