Oligomeric acylphloroglucinols from Myrtle (Myrtus communis)

Giovanni Appendino; Federica Bianchi; Alberto Minassi; Olov Sterner; Mauro Ballero; Simon Gibbons

doi:10.1021/np010441b

Oligomeric acylphloroglucinols from Myrtle (Myrtus communis)

Giovanni Appendino, Federica Bianchi, Alberto Minassi, Olov Sterner, Mauro Ballero, Simon Gibbons

Research output: Contribution to journal › Article › peer-review

92 Citations (Scopus)

Abstract

The dimeric nonprenylated acylphloroglucinol semimyrtucommulone (6) was obtained from the leaves of myrtle (Myrtus communis) as a 2:1 mixture of two rotamers. The known trimeric phloroglucinol myrtucommulone A (1) was also isolated and characterized spectroscopically as a silylated cyclized derivative (5). Myrtucommulone A showed significant antibacterial activity against multidrug-resistant (MDR) clinically relevant bacteria, while semimyrtucommulone was less active.

Original language	English
Pages (from-to)	334-338
Number of pages	5
Journal	Journal of Natural Products
Volume	65
Issue number	3
DOIs	https://doi.org/10.1021/np010441b
Publication status	Published - 1 Mar 2002

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10.1021/np010441b

https://pubs.acs.org/doi/10.1021/np010441b

Cite this

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abstract = "The dimeric nonprenylated acylphloroglucinol semimyrtucommulone (6) was obtained from the leaves of myrtle (Myrtus communis) as a 2:1 mixture of two rotamers. The known trimeric phloroglucinol myrtucommulone A (1) was also isolated and characterized spectroscopically as a silylated cyclized derivative (5). Myrtucommulone A showed significant antibacterial activity against multidrug-resistant (MDR) clinically relevant bacteria, while semimyrtucommulone was less active. ",

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AU - Appendino, Giovanni

AU - Bianchi, Federica

AU - Minassi, Alberto

AU - Sterner, Olov

AU - Ballero, Mauro

AU - Gibbons, Simon

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N2 - The dimeric nonprenylated acylphloroglucinol semimyrtucommulone (6) was obtained from the leaves of myrtle (Myrtus communis) as a 2:1 mixture of two rotamers. The known trimeric phloroglucinol myrtucommulone A (1) was also isolated and characterized spectroscopically as a silylated cyclized derivative (5). Myrtucommulone A showed significant antibacterial activity against multidrug-resistant (MDR) clinically relevant bacteria, while semimyrtucommulone was less active.

AB - The dimeric nonprenylated acylphloroglucinol semimyrtucommulone (6) was obtained from the leaves of myrtle (Myrtus communis) as a 2:1 mixture of two rotamers. The known trimeric phloroglucinol myrtucommulone A (1) was also isolated and characterized spectroscopically as a silylated cyclized derivative (5). Myrtucommulone A showed significant antibacterial activity against multidrug-resistant (MDR) clinically relevant bacteria, while semimyrtucommulone was less active.

U2 - 10.1021/np010441b

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