Oligomeric Acylphloroglucinols from Myrtle (Myrtus communis)

Giovanni Appendino; Federica Bianchi; Alberto Minassi; Olov Sterner; Mauro Ballero; Simon Gibbons

doi:10.1021/np010441b

Oligomeric Acylphloroglucinols from Myrtle (Myrtus communis)

Giovanni Appendino, Federica Bianchi, Alberto Minassi, Olov Sterner, Mauro Ballero, Simon Gibbons

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

90 Citations (Scopus)

Abstract

The dimeric nonprenylated acylphloroglucinol semimyrtucommulone (6) was obtained from the leaves of myrtle (Myrtus communis) as a 2:1 mixture of two rotamers. The known trimeric phloroglucinol myrtucommulone A (1) was also isolated and characterized spectroscopically as a silylated cyclized derivative (5). Myrtucommulone A showed significant antibacterial activity against multidrug-resistant (MDR) clinically relevant bacteria, while semimyrtucommulone was less active.

Original language	English
Pages (from-to)	334-338
Number of pages	5
Journal	Journal of Natural Products
Volume	65
Issue number	3
DOIs	https://doi.org/10.1021/np010441b
Publication status	Published - 1 Mar 2002

Access to Document

10.1021/np010441b

https://pubs.acs.org/doi/10.1021/np010441b

Cite this

@article{9818deb1e3b34c718256fa3ae2063a3b,

title = "Oligomeric Acylphloroglucinols from Myrtle (Myrtus communis)",

abstract = "The dimeric nonprenylated acylphloroglucinol semimyrtucommulone (6) was obtained from the leaves of myrtle (Myrtus communis) as a 2:1 mixture of two rotamers. The known trimeric phloroglucinol myrtucommulone A (1) was also isolated and characterized spectroscopically as a silylated cyclized derivative (5). Myrtucommulone A showed significant antibacterial activity against multidrug-resistant (MDR) clinically relevant bacteria, while semimyrtucommulone was less active. ",

author = "Giovanni Appendino and Federica Bianchi and Alberto Minassi and Olov Sterner and Mauro Ballero and Simon Gibbons",

year = "2002",

month = mar,

day = "1",

doi = "10.1021/np010441b",

language = "English",

volume = "65",

pages = "334--338",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "3",

}

TY - JOUR

T1 - Oligomeric Acylphloroglucinols from Myrtle (Myrtus communis)

AU - Appendino, Giovanni

AU - Bianchi, Federica

AU - Minassi, Alberto

AU - Sterner, Olov

AU - Ballero, Mauro

AU - Gibbons, Simon

PY - 2002/3/1

Y1 - 2002/3/1

N2 - The dimeric nonprenylated acylphloroglucinol semimyrtucommulone (6) was obtained from the leaves of myrtle (Myrtus communis) as a 2:1 mixture of two rotamers. The known trimeric phloroglucinol myrtucommulone A (1) was also isolated and characterized spectroscopically as a silylated cyclized derivative (5). Myrtucommulone A showed significant antibacterial activity against multidrug-resistant (MDR) clinically relevant bacteria, while semimyrtucommulone was less active.

AB - The dimeric nonprenylated acylphloroglucinol semimyrtucommulone (6) was obtained from the leaves of myrtle (Myrtus communis) as a 2:1 mixture of two rotamers. The known trimeric phloroglucinol myrtucommulone A (1) was also isolated and characterized spectroscopically as a silylated cyclized derivative (5). Myrtucommulone A showed significant antibacterial activity against multidrug-resistant (MDR) clinically relevant bacteria, while semimyrtucommulone was less active.

U2 - 10.1021/np010441b

DO - 10.1021/np010441b

M3 - Article

VL - 65

SP - 334

EP - 338

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 3

ER -