Abstract
The composite likelihood (CL) is amongst the computational methods used for estimation of the generalized linear mixed model (GLMM) in the context of bivariate meta-analysis of diagnostic test accuracy studies. Its advantage is that the likelihood can be derived conveniently under the assumption of independence between the random effects, but there has not been a clear analysis of the merit or necessity of this method. For synthesis of diagnostic test accuracy studies, a copula mixed model has been proposed in the biostatistics literature. This general model includes the GLMM as a special case and can also allow for flexible dependence modelling, different from assuming simple linear correlation structures, normality and tail independence in the joint tails. A maximum likelihood (ML) method, which is based on evaluating the bi-dimensional integrals of the likelihood with quadrature methods has been proposed, and in fact it eases any computational difficulty that might be caused by the double integral in the likelihood function. Both methods are thoroughly examined with extensive simulations and illustrated with data of a published meta-analysis. It is shown that the ML method has non-convergence issues or computational difficulties and at the same time allows estimation of the dependence between study-specific sensitivity and specificity and thus prediction via summary receiver operating curves.
Original language | English |
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Pages (from-to) | 211-227 |
Number of pages | 17 |
Journal | AStA Advances in Statistical Analysis |
Volume | 102 |
Issue number | 2 |
Early online date | 20 Jun 2017 |
DOIs | |
Publication status | Published - Apr 2018 |
Keywords
- Copula mixed model
- diagnostic odds ratio
- generalized linear mixed model
- sensitivity/specificity
- SROC
Profiles
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Aristidis K. Nikoloulopoulos
- School of Engineering, Mathematics and Physics - Associate Professor in Statistics
- Numerical Simulation, Statistics & Data Science - Member
Person: Research Group Member, Academic, Teaching & Research