Orange juice-derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease

Manuel Y. Schär, Peter J. Curtis, Sara Hazim, Luisa M. Ostertag, Colin D. Kay, John F. Potter, Aedín Cassidy

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)


Epidemiologic data suggest inverse associations between citrus flavanone intake and cardiovascular disease (CVD) risk. However, insufficient randomized controlled trial data limit our understanding of the mechanisms by which flavanones and their metabolites potentially reduce cardiovascular risk factors.
Original languageEnglish
Pages (from-to)931-938
Number of pages8
JournalThe American Journal of Clinical Nutrition
Issue number5
Early online date18 Mar 2015
Publication statusPublished - 1 May 2015


  • flavonoids
  • flavanones
  • phenolic metabolites
  • randomized controlled trial
  • vascular function

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