Orange juice-derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: A randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease

Manuel Y. Schär; Peter J. Curtis; Sara Hazim; Luisa M. Ostertag; Colin D. Kay; John F. Potter; Aedín Cassidy

doi:10.3945/ajcn.114.104364

Orange juice-derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: A randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease

Manuel Y. Schär
, Peter J. Curtis
, Sara Hazim
, Luisa M. Ostertag
, Colin D. Kay
, John F. Potter
, Aedín Cassidy

Research output: Contribution to journal › Article › peer-review

67 Citations (Scopus)

Abstract

Epidemiologic data suggest inverse associations between citrus flavanone intake and cardiovascular disease (CVD) risk. However, insufficient randomized controlled trial data limit our understanding of the mechanisms by which flavanones and their metabolites potentially reduce cardiovascular risk factors.

Original language	English
Pages (from-to)	931-938
Number of pages	8
Journal	The American Journal of Clinical Nutrition
Volume	101
Issue number	5
Early online date	18 Mar 2015
DOIs	https://doi.org/10.3945/ajcn.114.104364
Publication status	Published - 1 May 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

flavonoids
flavanones
phenolic metabolites
randomized controlled trial
vascular function

Access to Document

10.3945/ajcn.114.104364Licence: CC BY

Peter Curtis
- P.Curtisuea.acuk
- Norwich Medical School - Associate Professor
- Norwich Institute for Healthy Aging - Member
- Metabolic Health - Member
- Nutrition and Preventive Medicine - Member
Person: Research Group Member, Research Centre Member, Academic, Teaching and Research
John Potter
- John.Potteruea.acuk
- Norwich Medical School - Emeritus Professor
- Metabolic Health - Member
- Cardiovascular and Metabolic Health - Member
Person: Honorary, Research Group Member, Research Centre Member

The collective bioactivity of dietary flavonoids: importance of specific structural characteristics for cardiovascular benefits
Kay, C. (Principal Investigator), Cassidy, A. (Co-Investigator) & O'Connell, M. (Co-Investigator)
Biotechnology and Biological Sciences Research Council
28/03/11 → 27/03/14
Project: Research
Effects of Fruit Juice Processing and Human Metabolism on the Functionality of Anthocyanins for Cardiovascular Health (DRINC)
Kay, C. (Principal Investigator) & Cassidy, A. (Co-Investigator)
Biotechnology and Biological Sciences Research Council
1/02/10 → 31/01/13
Project: Research

Cite this

Schär, M. Y., Curtis, P. J., Hazim, S., Ostertag, L. M., Kay, C. D., Potter, J. F., & Cassidy, A. (2015). Orange juice-derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: A randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease. The American Journal of Clinical Nutrition, 101(5), 931-938. https://doi.org/10.3945/ajcn.114.104364

@article{bf6a50029434404b9b7e176fd48a4a06,

title = "Orange juice-derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: A randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease",

abstract = "Epidemiologic data suggest inverse associations between citrus flavanone intake and cardiovascular disease (CVD) risk. However, insufficient randomized controlled trial data limit our understanding of the mechanisms by which flavanones and their metabolites potentially reduce cardiovascular risk factors.",

keywords = "flavonoids, flavanones, phenolic metabolites, randomized controlled trial, vascular function",

author = "Sch{\"a}r, \{Manuel Y.\} and Curtis, \{Peter J.\} and Sara Hazim and Ostertag, \{Luisa M.\} and Kay, \{Colin D.\} and Potter, \{John F.\} and Aed{\'i}n Cassidy",

year = "2015",

month = may,

day = "1",

doi = "10.3945/ajcn.114.104364",

language = "English",

volume = "101",

pages = "931--938",

journal = "The American Journal of Clinical Nutrition",

issn = "0002-9165",

publisher = "Elsevier",

number = "5",

}

Schär, MY, Curtis, PJ, Hazim, S, Ostertag, LM, Kay, CD, Potter, JF & Cassidy, A 2015, 'Orange juice-derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: A randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease', The American Journal of Clinical Nutrition, vol. 101, no. 5, pp. 931-938. https://doi.org/10.3945/ajcn.114.104364

Orange juice-derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: A randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease. / Schär, Manuel Y.; Curtis, Peter J.; Hazim, Sara et al.
In: The American Journal of Clinical Nutrition, Vol. 101, No. 5, 01.05.2015, p. 931-938.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Orange juice-derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: A randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease

AU - Schär, Manuel Y.

AU - Curtis, Peter J.

AU - Hazim, Sara

AU - Ostertag, Luisa M.

AU - Kay, Colin D.

AU - Potter, John F.

AU - Cassidy, Aedín

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Epidemiologic data suggest inverse associations between citrus flavanone intake and cardiovascular disease (CVD) risk. However, insufficient randomized controlled trial data limit our understanding of the mechanisms by which flavanones and their metabolites potentially reduce cardiovascular risk factors.

AB - Epidemiologic data suggest inverse associations between citrus flavanone intake and cardiovascular disease (CVD) risk. However, insufficient randomized controlled trial data limit our understanding of the mechanisms by which flavanones and their metabolites potentially reduce cardiovascular risk factors.

KW - flavonoids

KW - flavanones

KW - phenolic metabolites

KW - randomized controlled trial

KW - vascular function

U2 - 10.3945/ajcn.114.104364

DO - 10.3945/ajcn.114.104364

M3 - Article

SN - 0002-9165

VL - 101

SP - 931

EP - 938

JO - The American Journal of Clinical Nutrition

JF - The American Journal of Clinical Nutrition

IS - 5

ER -

Schär MY, Curtis PJ, Hazim S, Ostertag LM, Kay CD, Potter JF et al. Orange juice-derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: A randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease. The American Journal of Clinical Nutrition. 2015 May 1;101(5):931-938. Epub 2015 Mar 18. doi: 10.3945/ajcn.114.104364

Orange juice-derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: A randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease

Abstract

UN SDGs

Keywords

Access to Document

Profiles

Peter Curtis

John Potter

Projects

The collective bioactivity of dietary flavonoids: importance of specific structural characteristics for cardiovascular benefits

Effects of Fruit Juice Processing and Human Metabolism on the Functionality of Anthocyanins for Cardiovascular Health (DRINC)

Cite this