Orbitofrontal dysfunction discriminates behavioral variant frontotemporal dementia from Alzheimer's disease

M Hornberger; S Savage; S Hsieh; E Mioshi; O Piguet; J R Hodges

doi:10.1159/000321670

Orbitofrontal dysfunction discriminates behavioral variant frontotemporal dementia from Alzheimer's disease

M Hornberger, S Savage, S Hsieh, E Mioshi, O Piguet, J R Hodges

Research output: Contribution to journal › Article › peer-review

95 Citations (Scopus)

Abstract

BACKGROUND: Behavioral variant frontotemporal dementia (bvFTD) patients show prefrontal cortex dysfunction and atrophy.

METHODS: We investigated whether executive function in conjunction with prefrontal cortex atrophy discriminates bvFTD and Alzheimer's disease (AD) patients efficiently at presentation.

RESULTS: AD and bvFTD patients were distinguishable by 89.5% on their performance of 3 executive tasks: the Hayling Test of Inhibitory Control, Digit Span Backward and Letter Fluency. Similarly, scan ratings showed that orbitofrontal cortex (OFC) and dorsolateral prefrontal cortex regions distinguish both patient groups. More importantly, employing the Hayling error score in conjunction with the OFC atrophy rating showed that 92% of patients can be correctly classified into bvFTD and AD.

CONCLUSION: A combination of OFC and disinhibition measures appears to be a powerful diagnostic tool in differentiating bvFTD from AD patients in this preliminary study.

Original language	English
Pages (from-to)	547-552
Number of pages	6
Journal	Dementia and Geriatric Cognitive Disorders
Volume	30
Issue number	6
DOIs	https://doi.org/10.1159/000321670
Publication status	Published - 2010

Keywords

Aged
Alzheimer Disease
Behavior
Brain
Diagnosis, Differential
Executive Function
Female
Frontotemporal Dementia
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Neuropsychological Tests

Access to Document

10.1159/000321670

Cite this

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title = "Orbitofrontal dysfunction discriminates behavioral variant frontotemporal dementia from Alzheimer's disease",

abstract = "BACKGROUND: Behavioral variant frontotemporal dementia (bvFTD) patients show prefrontal cortex dysfunction and atrophy. METHODS: We investigated whether executive function in conjunction with prefrontal cortex atrophy discriminates bvFTD and Alzheimer's disease (AD) patients efficiently at presentation. RESULTS: AD and bvFTD patients were distinguishable by 89.5% on their performance of 3 executive tasks: the Hayling Test of Inhibitory Control, Digit Span Backward and Letter Fluency. Similarly, scan ratings showed that orbitofrontal cortex (OFC) and dorsolateral prefrontal cortex regions distinguish both patient groups. More importantly, employing the Hayling error score in conjunction with the OFC atrophy rating showed that 92% of patients can be correctly classified into bvFTD and AD. CONCLUSION: A combination of OFC and disinhibition measures appears to be a powerful diagnostic tool in differentiating bvFTD from AD patients in this preliminary study. ",

keywords = "Aged, Alzheimer Disease, Behavior, Brain, Diagnosis, Differential, Executive Function, Female, Frontotemporal Dementia, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests",

author = "M Hornberger and S Savage and S Hsieh and E Mioshi and O Piguet and Hodges, {J R}",

note = "Copyright {\textcopyright} 2011 S. Karger AG, Basel.",

year = "2010",

doi = "10.1159/000321670",

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journal = "Dementia and Geriatric Cognitive Disorders",

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T1 - Orbitofrontal dysfunction discriminates behavioral variant frontotemporal dementia from Alzheimer's disease

AU - Hornberger, M

AU - Savage, S

AU - Hsieh, S

AU - Mioshi, E

AU - Piguet, O

AU - Hodges, J R

PY - 2010

Y1 - 2010

N2 - BACKGROUND: Behavioral variant frontotemporal dementia (bvFTD) patients show prefrontal cortex dysfunction and atrophy. METHODS: We investigated whether executive function in conjunction with prefrontal cortex atrophy discriminates bvFTD and Alzheimer's disease (AD) patients efficiently at presentation. RESULTS: AD and bvFTD patients were distinguishable by 89.5% on their performance of 3 executive tasks: the Hayling Test of Inhibitory Control, Digit Span Backward and Letter Fluency. Similarly, scan ratings showed that orbitofrontal cortex (OFC) and dorsolateral prefrontal cortex regions distinguish both patient groups. More importantly, employing the Hayling error score in conjunction with the OFC atrophy rating showed that 92% of patients can be correctly classified into bvFTD and AD. CONCLUSION: A combination of OFC and disinhibition measures appears to be a powerful diagnostic tool in differentiating bvFTD from AD patients in this preliminary study.

AB - BACKGROUND: Behavioral variant frontotemporal dementia (bvFTD) patients show prefrontal cortex dysfunction and atrophy. METHODS: We investigated whether executive function in conjunction with prefrontal cortex atrophy discriminates bvFTD and Alzheimer's disease (AD) patients efficiently at presentation. RESULTS: AD and bvFTD patients were distinguishable by 89.5% on their performance of 3 executive tasks: the Hayling Test of Inhibitory Control, Digit Span Backward and Letter Fluency. Similarly, scan ratings showed that orbitofrontal cortex (OFC) and dorsolateral prefrontal cortex regions distinguish both patient groups. More importantly, employing the Hayling error score in conjunction with the OFC atrophy rating showed that 92% of patients can be correctly classified into bvFTD and AD. CONCLUSION: A combination of OFC and disinhibition measures appears to be a powerful diagnostic tool in differentiating bvFTD from AD patients in this preliminary study.

KW - Aged

KW - Alzheimer Disease

KW - Behavior

KW - Brain

KW - Diagnosis, Differential

KW - Executive Function

KW - Female

KW - Frontotemporal Dementia

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Neuropsychological Tests

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DO - 10.1159/000321670

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VL - 30

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JO - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

SN - 1420-8008

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