TY - JOUR
T1 - Origin of OXA-23 variant OXA-239 from a recently emerged lineage of Acinetobacter baumannii International Clone V
AU - Grana-Miraglia, Lucia
AU - Evans, Ben
AU - Lopez Jacome, Luis
AU - Hernández-Durán, Melissa
AU - Colín-Castro, Claudia
AU - Volkow-Fernández, Patricia
AU - Cevallos, Miguel
AU - Franco-Cendejas, Rafael
AU - Castillo-Ramirez, Santiago
N1 - Copyright © 2020 Graña-Miraglia et al.
PY - 2020/1/8
Y1 - 2020/1/8
N2 - Over the last few decades, carbapenemase-producing Acinetobacter baumannii has become a major cause of nosocomial infections all over the world. However, the genome identity of lineages of this species in Latin America has not been studied as much as in developed countries. Here, through a population genomics approach considering the whole genomes of 148 isolates (almost 40 from Mexico and Honduras), we describe the recent emergence of the lineage sequence type 758 (ST758), which belongs to the international clone V and has spread out to Canada, Mexico, Honduras, and Colombia. Notably, this lineage was found to coexist with other A. baumannii lineages in hospitals in Mexico and Honduras. Isolates from this lineage show considerable variation in antibiotic resistance profiles, but most of them are resistant to carbapenems. Moreover, we found a variety of acquired oxacillinase (OXA) families within this lineage and tracked the very recent inception, and subsequent horizontal transmission, of the OXA-239 carbapenemase. This work highlights the urgent need to investigate recently emerged lineages of this species in Latin America and elsewhere, as these might harbor novel antibiotic resistance genes.
AB - Over the last few decades, carbapenemase-producing Acinetobacter baumannii has become a major cause of nosocomial infections all over the world. However, the genome identity of lineages of this species in Latin America has not been studied as much as in developed countries. Here, through a population genomics approach considering the whole genomes of 148 isolates (almost 40 from Mexico and Honduras), we describe the recent emergence of the lineage sequence type 758 (ST758), which belongs to the international clone V and has spread out to Canada, Mexico, Honduras, and Colombia. Notably, this lineage was found to coexist with other A. baumannii lineages in hospitals in Mexico and Honduras. Isolates from this lineage show considerable variation in antibiotic resistance profiles, but most of them are resistant to carbapenems. Moreover, we found a variety of acquired oxacillinase (OXA) families within this lineage and tracked the very recent inception, and subsequent horizontal transmission, of the OXA-239 carbapenemase. This work highlights the urgent need to investigate recently emerged lineages of this species in Latin America and elsewhere, as these might harbor novel antibiotic resistance genes.
KW - Acinetobacter baumannii
KW - EVOLUTION
KW - GLOBAL SPREAD
KW - HOSPITALS
KW - IC5
KW - OXA
KW - OXA beta-lactamases
KW - OXA-239
KW - TOOL
KW - evolutionary biology
KW - genome analysis
KW - infectious diseases
KW - international clones
KW - molecular epidemiology
KW - population genomics
UR - http://www.scopus.com/inward/record.url?scp=85077689764&partnerID=8YFLogxK
U2 - 10.1128/mSphere.00801-19
DO - 10.1128/mSphere.00801-19
M3 - Article
C2 - 31915222
VL - 5
JO - mSphere
JF - mSphere
SN - 2379-5042
IS - 1
M1 - e00801
ER -