Origin of OXA-23 variant OXA-239 from a recently emerged lineage of Acinetobacter baumannii International Clone V

Lucia Grana-Miraglia (Lead Author), Ben Evans (Lead Author), Luis Lopez Jacome, Melissa Hernández-Durán, Claudia Colín-Castro, Patricia Volkow-Fernández, Miguel Cevallos, Rafael Franco-Cendejas, Santiago Castillo-Ramirez

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Abstract

Over the last few decades, carbapenemase-producing Acinetobacter baumannii has become a major cause of nosocomial infections all over the world. However, the genome identity of lineages of this species in Latin America has not been studied as much as in developed countries. Here, through a population genomics approach considering the whole genomes of 148 isolates (almost 40 from Mexico and Honduras), we describe the recent emergence of the lineage sequence type 758 (ST758), which belongs to the international clone V and has spread out to Canada, Mexico, Honduras, and Colombia. Notably, this lineage was found to coexist with other A. baumannii lineages in hospitals in Mexico and Honduras. Isolates from this lineage show considerable variation in antibiotic resistance profiles, but most of them are resistant to carbapenems. Moreover, we found a variety of acquired oxacillinase (OXA) families within this lineage and tracked the very recent inception, and subsequent horizontal transmission, of the OXA-239 carbapenemase. This work highlights the urgent need to investigate recently emerged lineages of this species in Latin America and elsewhere, as these might harbor novel antibiotic resistance genes.
Original languageEnglish
Article numbere00801
JournalmSphere
Volume5
Issue number1
DOIs
Publication statusPublished - 8 Jan 2020

Keywords

  • Acinetobacter baumannii
  • EVOLUTION
  • GLOBAL SPREAD
  • HOSPITALS
  • IC5
  • OXA
  • OXA beta-lactamases
  • OXA-239
  • TOOL
  • evolutionary biology
  • genome analysis
  • infectious diseases
  • international clones
  • molecular epidemiology
  • population genomics

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