Origins and genetic legacy of prehistoric dogs

Anders Bergström; Laurent Frantz; Ryan Schmidt; Erik Ersmark; Ophelie Lebrasseur; Linus Girdland-Flink; Audrey T. Lin; Jan Storå; Karl-Göran Sjögren; David Anthony; Ekaterina Antipina; Sarieh Amiri; Guy Bar-Oz; Vladimir I. Bazaliiskii; Jelena Bulatović; Dorcas Brown; Alberto Carmagnini; Tom Davy; Sergey Fedorov; Ivana Fiore; Deirdre Fulton; Mietje Germonpré; James Haile; Evan K. Irving-Pease; Alexandra Jamieson; Luc Janssens; Irina Kirillova; Liora Kolska Horwitz; Julka Kuzmanovic-Cvetković; Yaroslav Kuzmin; Robert J. Losey; Daria Ložnjak Dizdar; Marjan Mashkour; Mario Novak; Vedat Onar; David Orton; Maja Pasarić; Miljana Radivojević; Dragana Rajković; Benjamin Roberts; Hannah Ryan; Mikhail Sablin; Fedor Shidlovskiy; Ivana Stojanović; Antonio Tagliacozzo; Katerina Trantalidou; Inga Ullén; Aritza Villaluenga; Paula Wapnish; Keith Dobney; Anders Götherström; Anna Linderholm; Love Dalén; Ron Pinhasi; Greger Larson; Pontus Skoglund

doi:10.1126/science.aba9572

Origins and genetic legacy of prehistoric dogs

Anders Bergström, Laurent Frantz, Ryan Schmidt, Erik Ersmark, Ophelie Lebrasseur, Linus Girdland-Flink, Audrey T. Lin, Jan Storå, Karl-Göran Sjögren, David Anthony, Ekaterina Antipina, Sarieh Amiri, Guy Bar-Oz, Vladimir I. Bazaliiskii, Jelena Bulatović, Dorcas Brown, Alberto Carmagnini, Tom Davy, Sergey Fedorov, Ivana FioreDeirdre Fulton, Mietje Germonpré, James Haile, Evan K. Irving-Pease, Alexandra Jamieson, Luc Janssens, Irina Kirillova, Liora Kolska Horwitz, Julka Kuzmanovic-Cvetković, Yaroslav Kuzmin, Robert J. Losey, Daria Ložnjak Dizdar, Marjan Mashkour, Mario Novak, Vedat Onar, David Orton, Maja Pasarić, Miljana Radivojević, Dragana Rajković, Benjamin Roberts, Hannah Ryan, Mikhail Sablin, Fedor Shidlovskiy, Ivana Stojanović, Antonio Tagliacozzo, Katerina Trantalidou, Inga Ullén, Aritza Villaluenga, Paula Wapnish, Keith Dobney, Anders Götherström, Anna Linderholm, Love Dalén, Ron Pinhasi, Greger Larson, Pontus Skoglund

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Abstract

Dogs were the first domestic animal, but little is known about their population history and to what extent it was linked to humans. We sequenced 27 ancient dog genomes and found that all dogs share a common ancestry distinct from present-day wolves, with limited gene flow from wolves since domestication but substantial dog-to-wolf gene flow. By 11,000 years ago, at least five major ancestry lineages had diversified, demonstrating a deep genetic history of dogs during the Paleolithic. Coanalysis with human genomes reveals aspects of dog population history that mirror humans, including Levant-related ancestry in Africa and early agricultural Europe. Other aspects differ, including the impacts of steppe pastoralist expansions in West and East Eurasia and a near-complete turnover of Neolithic European dog ancestry.

Original language	English
Pages (from-to)	557-564
Number of pages	8
Journal	Science
Volume	370
Issue number	6516
DOIs	https://doi.org/10.1126/science.aba9572
Publication status	Published - 30 Oct 2020

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Bergström, A., Frantz, L., Schmidt, R., Ersmark, E., Lebrasseur, O., Girdland-Flink, L., Lin, A. T., Storå, J., Sjögren, K-G., Anthony, D., Antipina, E., Amiri, S., Bar-Oz, G., Bazaliiskii, V. I., Bulatović, J., Brown, D., Carmagnini, A., Davy, T., Fedorov, S., ... Skoglund, P. (2020). Origins and genetic legacy of prehistoric dogs. Science, 370(6516), 557-564. https://doi.org/10.1126/science.aba9572

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title = "Origins and genetic legacy of prehistoric dogs",

abstract = "Dogs were the first domestic animal, but little is known about their population history and to what extent it was linked to humans. We sequenced 27 ancient dog genomes and found that all dogs share a common ancestry distinct from present-day wolves, with limited gene flow from wolves since domestication but substantial dog-to-wolf gene flow. By 11,000 years ago, at least five major ancestry lineages had diversified, demonstrating a deep genetic history of dogs during the Paleolithic. Coanalysis with human genomes reveals aspects of dog population history that mirror humans, including Levant-related ancestry in Africa and early agricultural Europe. Other aspects differ, including the impacts of steppe pastoralist expansions in West and East Eurasia and a near-complete turnover of Neolithic European dog ancestry.",

author = "Anders Bergstr{\"o}m and Laurent Frantz and Ryan Schmidt and Erik Ersmark and Ophelie Lebrasseur and Linus Girdland-Flink and Lin, {Audrey T.} and Jan Stor{\aa} and Karl-G{\"o}ran Sj{\"o}gren and David Anthony and Ekaterina Antipina and Sarieh Amiri and Guy Bar-Oz and Bazaliiskii, {Vladimir I.} and Jelena Bulatovi{\'c} and Dorcas Brown and Alberto Carmagnini and Tom Davy and Sergey Fedorov and Ivana Fiore and Deirdre Fulton and Mietje Germonpr{\'e} and James Haile and Irving-Pease, {Evan K.} and Alexandra Jamieson and Luc Janssens and Irina Kirillova and Horwitz, {Liora Kolska} and Julka Kuzmanovic-Cvetkovi{\'c} and Yaroslav Kuzmin and Losey, {Robert J.} and Dizdar, {Daria Lo{\v z}njak} and Marjan Mashkour and Mario Novak and Vedat Onar and David Orton and Maja Pasari{\'c} and Miljana Radivojevi{\'c} and Dragana Rajkovi{\'c} and Benjamin Roberts and Hannah Ryan and Mikhail Sablin and Fedor Shidlovskiy and Ivana Stojanovi{\'c} and Antonio Tagliacozzo and Katerina Trantalidou and Inga Ull{\'e}n and Aritza Villaluenga and Paula Wapnish and Keith Dobney and Anders G{\"o}therstr{\"o}m and Anna Linderholm and Love Dal{\'e}n and Ron Pinhasi and Greger Larson and Pontus Skoglund",

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Bergström, A, Frantz, L, Schmidt, R, Ersmark, E, Lebrasseur, O, Girdland-Flink, L, Lin, AT, Storå, J, Sjögren, K-G, Anthony, D, Antipina, E, Amiri, S, Bar-Oz, G, Bazaliiskii, VI, Bulatović, J, Brown, D, Carmagnini, A, Davy, T, Fedorov, S, Fiore, I, Fulton, D, Germonpré, M, Haile, J, Irving-Pease, EK, Jamieson, A, Janssens, L, Kirillova, I, Horwitz, LK, Kuzmanovic-Cvetković, J, Kuzmin, Y, Losey, RJ, Dizdar, DL, Mashkour, M, Novak, M, Onar, V, Orton, D, Pasarić, M, Radivojević, M, Rajković, D, Roberts, B, Ryan, H, Sablin, M, Shidlovskiy, F, Stojanović, I, Tagliacozzo, A, Trantalidou, K, Ullén, I, Villaluenga, A, Wapnish, P, Dobney, K, Götherström, A, Linderholm, A, Dalén, L, Pinhasi, R, Larson, G & Skoglund, P 2020, 'Origins and genetic legacy of prehistoric dogs', Science, vol. 370, no. 6516, pp. 557-564. https://doi.org/10.1126/science.aba9572

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AU - Frantz, Laurent

AU - Schmidt, Ryan

AU - Ersmark, Erik

AU - Lebrasseur, Ophelie

AU - Girdland-Flink, Linus

AU - Lin, Audrey T.

AU - Storå, Jan

AU - Sjögren, Karl-Göran

AU - Anthony, David

AU - Antipina, Ekaterina

AU - Amiri, Sarieh

AU - Bar-Oz, Guy

AU - Bazaliiskii, Vladimir I.

AU - Bulatović, Jelena

AU - Brown, Dorcas

AU - Carmagnini, Alberto

AU - Davy, Tom

AU - Fedorov, Sergey

AU - Fiore, Ivana

AU - Fulton, Deirdre

AU - Germonpré, Mietje

AU - Haile, James

AU - Irving-Pease, Evan K.

AU - Jamieson, Alexandra

AU - Janssens, Luc

AU - Kirillova, Irina

AU - Horwitz, Liora Kolska

AU - Kuzmanovic-Cvetković, Julka

AU - Kuzmin, Yaroslav

AU - Losey, Robert J.

AU - Dizdar, Daria Ložnjak

AU - Mashkour, Marjan

AU - Novak, Mario

AU - Onar, Vedat

AU - Orton, David

AU - Pasarić, Maja

AU - Radivojević, Miljana

AU - Rajković, Dragana

AU - Roberts, Benjamin

AU - Ryan, Hannah

AU - Sablin, Mikhail

AU - Shidlovskiy, Fedor

AU - Stojanović, Ivana

AU - Tagliacozzo, Antonio

AU - Trantalidou, Katerina

AU - Ullén, Inga

AU - Villaluenga, Aritza

AU - Wapnish, Paula

AU - Dobney, Keith

AU - Götherström, Anders

AU - Linderholm, Anna

AU - Dalén, Love

AU - Pinhasi, Ron

AU - Larson, Greger

AU - Skoglund, Pontus

PY - 2020/10/30

Y1 - 2020/10/30

N2 - Dogs were the first domestic animal, but little is known about their population history and to what extent it was linked to humans. We sequenced 27 ancient dog genomes and found that all dogs share a common ancestry distinct from present-day wolves, with limited gene flow from wolves since domestication but substantial dog-to-wolf gene flow. By 11,000 years ago, at least five major ancestry lineages had diversified, demonstrating a deep genetic history of dogs during the Paleolithic. Coanalysis with human genomes reveals aspects of dog population history that mirror humans, including Levant-related ancestry in Africa and early agricultural Europe. Other aspects differ, including the impacts of steppe pastoralist expansions in West and East Eurasia and a near-complete turnover of Neolithic European dog ancestry.

AB - Dogs were the first domestic animal, but little is known about their population history and to what extent it was linked to humans. We sequenced 27 ancient dog genomes and found that all dogs share a common ancestry distinct from present-day wolves, with limited gene flow from wolves since domestication but substantial dog-to-wolf gene flow. By 11,000 years ago, at least five major ancestry lineages had diversified, demonstrating a deep genetic history of dogs during the Paleolithic. Coanalysis with human genomes reveals aspects of dog population history that mirror humans, including Levant-related ancestry in Africa and early agricultural Europe. Other aspects differ, including the impacts of steppe pastoralist expansions in West and East Eurasia and a near-complete turnover of Neolithic European dog ancestry.

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U2 - 10.1126/science.aba9572

DO - 10.1126/science.aba9572

M3 - Article

VL - 370

SP - 557

EP - 564

JO - Science

JF - Science

SN - 0036-8075

IS - 6516

ER -

Origins and genetic legacy of prehistoric dogs

Abstract

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