Osteopontin is extensively expressed by macrophages following CNS demyelination but has a redundant role in remyelination

Chao Zhao, Stephen P.J. Fancy, Charles ffrench-Constant, Robin J.M. Franklin

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Osteopontin (OPN) is a key immunoregulator in the autoimmune-mediated demyelinating disease multiple sclerosis. OPN may also play a role in the remyelination since it is 1) a ligand for αV integrins, several of which regulate the properties of the oligodendrocyte precursor cells (OPCs) primarily responsible for remyelination, and 2) enhances myelin membrane formation in OPC lines. Here we show that OPN is expressed at high levels during remyelination of toxin-induced demyelination. The increased expression is due to mRNA expression in macrophages and follows differences in macrophage responses to demyelination in young and old adult animals. To identify the role of OPN in remyelination focal demyelination was induced in wild-type and OPN-/- mice. There was no difference in the rate of remyelination between the two groups indicating that OPN is not a critical component of remyelination.

Original languageEnglish
Pages (from-to)209-217
Number of pages9
JournalNeurobiology of Disease
Volume31
Issue number2
DOIs
Publication statusPublished - Aug 2008

Keywords

  • Demyelination
  • Knockout
  • Multiple sclerosis
  • Myelin
  • Oligodendrocyte precursor cell
  • Osteopontin
  • Regeneration
  • Remyelination

Cite this