TY - JOUR
T1 - Ostruthin: An Antimycobacterial Coumarin from the Roots of Peucedanum ostruthium
AU - Schinkovitz, Andreas
AU - Gibbons, Simon
AU - Stavri, Michael
AU - Cocksedge, Michael J.
AU - Bucar, Franz
PY - 2003/4/1
Y1 - 2003/4/1
N2 - Following a bioassay-guided fractionation, ostruthin (6-geranyl-7-hydroxycoumarin) was isolated from the roots of Peucedanum ostruthium Koch (Apiaceae) as a compound with pronounced in vitro activity against several species of rapidly growing Mycobacteria, namely Mycobacterium abscesus, M. aurum, M. fortuitum, M. phlei and M. smegmatis. Minimum inhibitory concentrations (MIC) ranged between 3.4 to 107.4 μM and were comparable to those of ethambutol and isoniazid. Imperatorin (8-isopent-2-enyloxy-6,7-furanocoumarin) showed no activity at concentrations up to 1.9 mM. Umbelliferone (7-hydroxycoumarin) was only weakly active (MIC = 0.79 mM).
AB - Following a bioassay-guided fractionation, ostruthin (6-geranyl-7-hydroxycoumarin) was isolated from the roots of Peucedanum ostruthium Koch (Apiaceae) as a compound with pronounced in vitro activity against several species of rapidly growing Mycobacteria, namely Mycobacterium abscesus, M. aurum, M. fortuitum, M. phlei and M. smegmatis. Minimum inhibitory concentrations (MIC) ranged between 3.4 to 107.4 μM and were comparable to those of ethambutol and isoniazid. Imperatorin (8-isopent-2-enyloxy-6,7-furanocoumarin) showed no activity at concentrations up to 1.9 mM. Umbelliferone (7-hydroxycoumarin) was only weakly active (MIC = 0.79 mM).
U2 - 10.1055/s-2003-38876
DO - 10.1055/s-2003-38876
M3 - Article
VL - 69
SP - 369
EP - 371
JO - Planta Medica
JF - Planta Medica
SN - 0032-0943
IS - 4
ER -