Ostruthin: An Antimycobacterial Coumarin from the Roots of Peucedanum ostruthium

Andreas Schinkovitz, Simon Gibbons, Michael Stavri, Michael J. Cocksedge, Franz Bucar

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Following a bioassay-guided fractionation, ostruthin (6-geranyl-7-hydroxycoumarin) was isolated from the roots of Peucedanum ostruthium Koch (Apiaceae) as a compound with pronounced in vitro activity against several species of rapidly growing Mycobacteria, namely Mycobacterium abscesus, M. aurum, M. fortuitum, M. phlei and M. smegmatis. Minimum inhibitory concentrations (MIC) ranged between 3.4 to 107.4 μM and were comparable to those of ethambutol and isoniazid. Imperatorin (8-isopent-2-enyloxy-6,7-furanocoumarin) showed no activity at concentrations up to 1.9 mM. Umbelliferone (7-hydroxycoumarin) was only weakly active (MIC = 0.79 mM).
Original languageEnglish
Pages (from-to)369-371
Number of pages3
JournalPlanta Medica
Volume69
Issue number4
DOIs
Publication statusPublished - 1 Apr 2003

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