Ostruthin: An antimycobacterial coumarin from the roots of Peucedanum ostruthium

Andreas Schinkovitz; Simon Gibbons; Michael Stavri; Michael J. Cocksedge; Franz Bucar

doi:10.1055/s-2003-38876

Ostruthin: An antimycobacterial coumarin from the roots of Peucedanum ostruthium

Andreas Schinkovitz
, Simon Gibbons
, Michael Stavri
, Michael J. Cocksedge
, Franz Bucar

Research output: Contribution to journal › Article › peer-review

88 Citations (Scopus)

Abstract

Following a bioassay-guided fractionation, ostruthin (6-geranyl-7-hydroxycoumarin) was isolated from the roots of Peucedanum ostruthium Koch (Apiaceae) as a compound with pronounced in vitro activity against several species of rapidly growing Mycobacteria, namely Mycobacterium abscesus, M. aurum, M. fortuitum, M. phlei and M. smegmatis. Minimum inhibitory concentrations (MIC) ranged between 3.4 to 107.4 μM and were comparable to those of ethambutol and isoniazid. Imperatorin (8-isopent-2-enyloxy-6,7-furanocoumarin) showed no activity at concentrations up to 1.9 mM. Umbelliferone (7-hydroxycoumarin) was only weakly active (MIC = 0.79 mM).

Original language	English
Pages (from-to)	369-371
Number of pages	3
Journal	Planta Medica
Volume	69
Issue number	4
DOIs	https://doi.org/10.1055/s-2003-38876
Publication status	Published - 1 Apr 2003

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10.1055/s-2003-38876

http://www.thieme-connect.de/DOI/DOI?10.1055/s-2003-38876

Cite this

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title = "Ostruthin: An antimycobacterial coumarin from the roots of Peucedanum ostruthium",

abstract = "Following a bioassay-guided fractionation, ostruthin (6-geranyl-7-hydroxycoumarin) was isolated from the roots of Peucedanum ostruthium Koch (Apiaceae) as a compound with pronounced in vitro activity against several species of rapidly growing Mycobacteria, namely Mycobacterium abscesus, M. aurum, M. fortuitum, M. phlei and M. smegmatis. Minimum inhibitory concentrations (MIC) ranged between 3.4 to 107.4 μM and were comparable to those of ethambutol and isoniazid. Imperatorin (8-isopent-2-enyloxy-6,7-furanocoumarin) showed no activity at concentrations up to 1.9 mM. Umbelliferone (7-hydroxycoumarin) was only weakly active (MIC = 0.79 mM).",

author = "Andreas Schinkovitz and Simon Gibbons and Michael Stavri and Cocksedge, \{Michael J.\} and Franz Bucar",

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doi = "10.1055/s-2003-38876",

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T1 - Ostruthin: An antimycobacterial coumarin from the roots of Peucedanum ostruthium

AU - Schinkovitz, Andreas

AU - Gibbons, Simon

AU - Stavri, Michael

AU - Cocksedge, Michael J.

AU - Bucar, Franz

PY - 2003/4/1

Y1 - 2003/4/1

N2 - Following a bioassay-guided fractionation, ostruthin (6-geranyl-7-hydroxycoumarin) was isolated from the roots of Peucedanum ostruthium Koch (Apiaceae) as a compound with pronounced in vitro activity against several species of rapidly growing Mycobacteria, namely Mycobacterium abscesus, M. aurum, M. fortuitum, M. phlei and M. smegmatis. Minimum inhibitory concentrations (MIC) ranged between 3.4 to 107.4 μM and were comparable to those of ethambutol and isoniazid. Imperatorin (8-isopent-2-enyloxy-6,7-furanocoumarin) showed no activity at concentrations up to 1.9 mM. Umbelliferone (7-hydroxycoumarin) was only weakly active (MIC = 0.79 mM).

AB - Following a bioassay-guided fractionation, ostruthin (6-geranyl-7-hydroxycoumarin) was isolated from the roots of Peucedanum ostruthium Koch (Apiaceae) as a compound with pronounced in vitro activity against several species of rapidly growing Mycobacteria, namely Mycobacterium abscesus, M. aurum, M. fortuitum, M. phlei and M. smegmatis. Minimum inhibitory concentrations (MIC) ranged between 3.4 to 107.4 μM and were comparable to those of ethambutol and isoniazid. Imperatorin (8-isopent-2-enyloxy-6,7-furanocoumarin) showed no activity at concentrations up to 1.9 mM. Umbelliferone (7-hydroxycoumarin) was only weakly active (MIC = 0.79 mM).

U2 - 10.1055/s-2003-38876

DO - 10.1055/s-2003-38876

M3 - Article

SN - 0032-0943

VL - 69

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JO - Planta Medica

JF - Planta Medica

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