Overexpression of angiopoietin-like protein 4 protects against atherosclerosis development

Anastasia Georgiadi, Yanan Wang, Rinke Stienstra, Nathanja Tjeerdema, Aafke Janssen, Anton Stalenhoef, J Adam van der Vliet, Albert de Roos, Jouke T Tamsma, Johannes W A Smit, Nguan Soon Tan, Michael Müller, Patrick C N Rensen, Sander Kersten

Research output: Contribution to journalArticlepeer-review

76 Citations (Scopus)


Macrophage foam cells play a crucial role in several pathologies including multiple sclerosis, glomerulosclerosis, and atherosclerosis. Angiopoietin-like protein 4 (Angptl4) was previously shown to inhibit chyle-induced foam cell formation in mesenteric lymph nodes. Here we characterized the regulation of Angptl4 expression in macrophages and examined the impact of Angptl4 on atherosclerosis development.
Original languageEnglish
Pages (from-to)1529-1537
Number of pages9
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Issue number7
Publication statusPublished - Jul 2013


  • Angiopoietins
  • Animals
  • Aorta
  • Aortic Diseases
  • Apolipoprotein E3
  • Atherosclerosis
  • Carotid Arteries
  • Carotid Stenosis
  • Cell Line
  • Chemotaxis
  • Cholesterol
  • Diet, High-Fat
  • Disease Models, Animal
  • Female
  • Foam Cells
  • Humans
  • Ligands
  • Lipoproteins, LDL
  • Macrophage Activation
  • Macrophages
  • Magnetic Resonance Imaging
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Middle Aged
  • Time Factors
  • Toll-Like Receptor 3
  • Toll-Like Receptor 4
  • Triglycerides
  • Up-Regulation

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