Overexpression of angiopoietin-like protein 4 protects against atherosclerosis development

Anastasia Georgiadi; Yanan Wang; Rinke Stienstra; Nathanja Tjeerdema; Aafke Janssen; Anton Stalenhoef; J Adam van der Vliet; Albert de Roos; Jouke T Tamsma; Johannes W A Smit; Nguan Soon Tan; Michael Müller; Patrick C N Rensen; Sander Kersten

doi:10.1161/ATVBAHA.113.301698

Overexpression of angiopoietin-like protein 4 protects against atherosclerosis development

Anastasia Georgiadi, Yanan Wang, Rinke Stienstra, Nathanja Tjeerdema, Aafke Janssen, Anton Stalenhoef, J Adam van der Vliet, Albert de Roos, Jouke T Tamsma, Johannes W A Smit, Nguan Soon Tan, Michael Müller, Patrick C N Rensen, Sander Kersten

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Abstract

Macrophage foam cells play a crucial role in several pathologies including multiple sclerosis, glomerulosclerosis, and atherosclerosis. Angiopoietin-like protein 4 (Angptl4) was previously shown to inhibit chyle-induced foam cell formation in mesenteric lymph nodes. Here we characterized the regulation of Angptl4 expression in macrophages and examined the impact of Angptl4 on atherosclerosis development.

Original language	English
Pages (from-to)	1529-1537
Number of pages	9
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	33
Issue number	7
DOIs	https://doi.org/10.1161/ATVBAHA.113.301698
Publication status	Published - Jul 2013

Keywords

Angiopoietins
Animals
Aorta
Aortic Diseases
Apolipoprotein E3
Atherosclerosis
Carotid Arteries
Carotid Stenosis
Cell Line
Chemotaxis
Cholesterol
Diet, High-Fat
Disease Models, Animal
Female
Foam Cells
Humans
Ligands
Lipoproteins, LDL
Macrophage Activation
Macrophages
Magnetic Resonance Imaging
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Middle Aged
Time Factors
Toll-Like Receptor 3
Toll-Like Receptor 4
Triglycerides
Up-Regulation

Access to Document

10.1161/ATVBAHA.113.301698

Cite this

Georgiadi, A., Wang, Y., Stienstra, R., Tjeerdema, N., Janssen, A., Stalenhoef, A., van der Vliet, J. A., de Roos, A., Tamsma, J. T., Smit, J. W. A., Tan, N. S., Müller, M., Rensen, P. C. N., & Kersten, S. (2013). Overexpression of angiopoietin-like protein 4 protects against atherosclerosis development. Arteriosclerosis, Thrombosis, and Vascular Biology, 33(7), 1529-1537. https://doi.org/10.1161/ATVBAHA.113.301698

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title = "Overexpression of angiopoietin-like protein 4 protects against atherosclerosis development",

abstract = "Macrophage foam cells play a crucial role in several pathologies including multiple sclerosis, glomerulosclerosis, and atherosclerosis. Angiopoietin-like protein 4 (Angptl4) was previously shown to inhibit chyle-induced foam cell formation in mesenteric lymph nodes. Here we characterized the regulation of Angptl4 expression in macrophages and examined the impact of Angptl4 on atherosclerosis development.",

keywords = "Angiopoietins, Animals, Aorta, Aortic Diseases, Apolipoprotein E3, Atherosclerosis, Carotid Arteries, Carotid Stenosis, Cell Line, Chemotaxis, Cholesterol, Diet, High-Fat, Disease Models, Animal, Female, Foam Cells, Humans, Ligands, Lipoproteins, LDL, Macrophage Activation, Macrophages, Magnetic Resonance Imaging, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Middle Aged, Time Factors, Toll-Like Receptor 3, Toll-Like Receptor 4, Triglycerides, Up-Regulation",

author = "Anastasia Georgiadi and Yanan Wang and Rinke Stienstra and Nathanja Tjeerdema and Aafke Janssen and Anton Stalenhoef and {van der Vliet}, {J Adam} and {de Roos}, Albert and Tamsma, {Jouke T} and Smit, {Johannes W A} and Tan, {Nguan Soon} and Michael M{\"u}ller and Rensen, {Patrick C N} and Sander Kersten",

year = "2013",

month = jul,

doi = "10.1161/ATVBAHA.113.301698",

language = "English",

volume = "33",

pages = "1529--1537",

journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",

issn = "1079-5642",

publisher = "Lippincott, Williams and Wilkins",

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}

Georgiadi, A, Wang, Y, Stienstra, R, Tjeerdema, N, Janssen, A, Stalenhoef, A, van der Vliet, JA, de Roos, A, Tamsma, JT, Smit, JWA, Tan, NS, Müller, M, Rensen, PCN & Kersten, S 2013, 'Overexpression of angiopoietin-like protein 4 protects against atherosclerosis development', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 33, no. 7, pp. 1529-1537. https://doi.org/10.1161/ATVBAHA.113.301698

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T1 - Overexpression of angiopoietin-like protein 4 protects against atherosclerosis development

AU - Georgiadi, Anastasia

AU - Wang, Yanan

AU - Stienstra, Rinke

AU - Tjeerdema, Nathanja

AU - Janssen, Aafke

AU - Stalenhoef, Anton

AU - van der Vliet, J Adam

AU - de Roos, Albert

AU - Tamsma, Jouke T

AU - Smit, Johannes W A

AU - Tan, Nguan Soon

AU - Müller, Michael

AU - Rensen, Patrick C N

AU - Kersten, Sander

PY - 2013/7

Y1 - 2013/7

N2 - Macrophage foam cells play a crucial role in several pathologies including multiple sclerosis, glomerulosclerosis, and atherosclerosis. Angiopoietin-like protein 4 (Angptl4) was previously shown to inhibit chyle-induced foam cell formation in mesenteric lymph nodes. Here we characterized the regulation of Angptl4 expression in macrophages and examined the impact of Angptl4 on atherosclerosis development.

AB - Macrophage foam cells play a crucial role in several pathologies including multiple sclerosis, glomerulosclerosis, and atherosclerosis. Angiopoietin-like protein 4 (Angptl4) was previously shown to inhibit chyle-induced foam cell formation in mesenteric lymph nodes. Here we characterized the regulation of Angptl4 expression in macrophages and examined the impact of Angptl4 on atherosclerosis development.

KW - Angiopoietins

KW - Animals

KW - Aorta

KW - Aortic Diseases

KW - Apolipoprotein E3

KW - Atherosclerosis

KW - Carotid Arteries

KW - Carotid Stenosis

KW - Cell Line

KW - Chemotaxis

KW - Cholesterol

KW - Diet, High-Fat

KW - Disease Models, Animal

KW - Female

KW - Foam Cells

KW - Humans

KW - Ligands

KW - Lipoproteins, LDL

KW - Macrophage Activation

KW - Macrophages

KW - Magnetic Resonance Imaging

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Transgenic

KW - Middle Aged

KW - Time Factors

KW - Toll-Like Receptor 3

KW - Toll-Like Receptor 4

KW - Triglycerides

KW - Up-Regulation

U2 - 10.1161/ATVBAHA.113.301698

DO - 10.1161/ATVBAHA.113.301698

M3 - Article

C2 - 23640487

SN - 1079-5642

VL - 33

SP - 1529

EP - 1537

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

IS - 7

ER -