Overexpression of RAD51 occurs in aggressive prostatic cancer

Anita Mitra, Charles Jameson, Yolanda Barbachano, Lydia Sanchez, Zsofia Kote-Jarai, Susan Peock, Nayanta Sodha, Elizabeth Bancroft, Anne Fletcher, Colin Cooper, Douglas Easton, Rosalind Eeles, Christopher S Foster, IMPACT Steering Committee and IMPACT and EMBRACE Collaborators

Research output: Contribution to journalArticlepeer-review

69 Citations (Scopus)

Abstract

To test the hypothesis that, in a matched series of prostatic cancers, either with or without BRCA1 or BRCA2 mutations, RAD51 protein expression is enhanced in association with BRCA mutation genotypes.
Original languageEnglish
Pages (from-to)696-704
Number of pages9
JournalHistopathology
Volume55
Issue number6
DOIs
Publication statusPublished - Dec 2009

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • BRCA1 Protein
  • BRCA2 Protein
  • Cell Count
  • Gene Expression Regulation, Neoplastic
  • Genetic Predisposition to Disease
  • Germ-Line Mutation
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Neoplasm Proteins
  • Prostatic Neoplasms
  • Rad51 Recombinase
  • Severity of Illness Index
  • Tumor Markers, Biological

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