Overexpression of RAD51 occurs in aggressive prostatic cancer

Anita Mitra; Charles Jameson; Yolanda Barbachano; Lydia Sanchez; Zsofia Kote-Jarai; Susan Peock; Nayanta Sodha; Elizabeth Bancroft; Anne Fletcher; Colin Cooper; Douglas Easton; Rosalind Eeles; Christopher S Foster; IMPACT Steering Committee and IMPACT and EMBRACE Collaborators

doi:10.1111/j.1365-2559.2009.03448.x

Overexpression of RAD51 occurs in aggressive prostatic cancer

Anita Mitra, Charles Jameson, Yolanda Barbachano, Lydia Sanchez, Zsofia Kote-Jarai, Susan Peock, Nayanta Sodha, Elizabeth Bancroft, Anne Fletcher, Colin Cooper, Douglas Easton, Rosalind Eeles, Christopher S Foster, IMPACT Steering Committee and IMPACT and EMBRACE Collaborators

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

Abstract

To test the hypothesis that, in a matched series of prostatic cancers, either with or without BRCA1 or BRCA2 mutations, RAD51 protein expression is enhanced in association with BRCA mutation genotypes.

Original language	English
Pages (from-to)	696-704
Number of pages	9
Journal	Histopathology
Volume	55
Issue number	6
DOIs	https://doi.org/10.1111/j.1365-2559.2009.03448.x
Publication status	Published - Dec 2009

Keywords

Adult
Aged
Aged, 80 and over
BRCA1 Protein
BRCA2 Protein
Cell Count
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Germ-Line Mutation
Humans
Immunohistochemistry
Male
Middle Aged
Neoplasm Proteins
Prostatic Neoplasms
Rad51 Recombinase
Severity of Illness Index
Tumor Markers, Biological

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/j.1365-2559.2009.03448.x

Cite this

Mitra, A., Jameson, C., Barbachano, Y., Sanchez, L., Kote-Jarai, Z., Peock, S., Sodha, N., Bancroft, E., Fletcher, A., Cooper, C., Easton, D., Eeles, R., Foster, C. S., & IMPACT Steering Committee and IMPACT and EMBRACE Collaborators (2009). Overexpression of RAD51 occurs in aggressive prostatic cancer. Histopathology, 55(6), 696-704. https://doi.org/10.1111/j.1365-2559.2009.03448.x

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title = "Overexpression of RAD51 occurs in aggressive prostatic cancer",

abstract = "To test the hypothesis that, in a matched series of prostatic cancers, either with or without BRCA1 or BRCA2 mutations, RAD51 protein expression is enhanced in association with BRCA mutation genotypes.",

keywords = "Adult, Aged, Aged, 80 and over, BRCA1 Protein, BRCA2 Protein, Cell Count, Gene Expression Regulation, Neoplastic, Genetic Predisposition to Disease, Germ-Line Mutation, Humans, Immunohistochemistry, Male, Middle Aged, Neoplasm Proteins, Prostatic Neoplasms, Rad51 Recombinase, Severity of Illness Index, Tumor Markers, Biological",

author = "Anita Mitra and Charles Jameson and Yolanda Barbachano and Lydia Sanchez and Zsofia Kote-Jarai and Susan Peock and Nayanta Sodha and Elizabeth Bancroft and Anne Fletcher and Colin Cooper and Douglas Easton and Rosalind Eeles and Foster, {Christopher S} and {IMPACT Steering Committee and IMPACT and EMBRACE Collaborators}",

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doi = "10.1111/j.1365-2559.2009.03448.x",

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volume = "55",

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journal = "Histopathology",

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Mitra, A, Jameson, C, Barbachano, Y, Sanchez, L, Kote-Jarai, Z, Peock, S, Sodha, N, Bancroft, E, Fletcher, A, Cooper, C, Easton, D, Eeles, R, Foster, CS & IMPACT Steering Committee and IMPACT and EMBRACE Collaborators 2009, 'Overexpression of RAD51 occurs in aggressive prostatic cancer', Histopathology, vol. 55, no. 6, pp. 696-704. https://doi.org/10.1111/j.1365-2559.2009.03448.x

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T1 - Overexpression of RAD51 occurs in aggressive prostatic cancer

AU - Mitra, Anita

AU - Jameson, Charles

AU - Barbachano, Yolanda

AU - Sanchez, Lydia

AU - Kote-Jarai, Zsofia

AU - Peock, Susan

AU - Sodha, Nayanta

AU - Bancroft, Elizabeth

AU - Fletcher, Anne

AU - Cooper, Colin

AU - Easton, Douglas

AU - Eeles, Rosalind

AU - Foster, Christopher S

AU - IMPACT Steering Committee and IMPACT and EMBRACE Collaborators

PY - 2009/12

Y1 - 2009/12

N2 - To test the hypothesis that, in a matched series of prostatic cancers, either with or without BRCA1 or BRCA2 mutations, RAD51 protein expression is enhanced in association with BRCA mutation genotypes.

AB - To test the hypothesis that, in a matched series of prostatic cancers, either with or without BRCA1 or BRCA2 mutations, RAD51 protein expression is enhanced in association with BRCA mutation genotypes.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - BRCA1 Protein

KW - BRCA2 Protein

KW - Cell Count

KW - Gene Expression Regulation, Neoplastic

KW - Genetic Predisposition to Disease

KW - Germ-Line Mutation

KW - Humans

KW - Immunohistochemistry

KW - Male

KW - Middle Aged

KW - Neoplasm Proteins

KW - Prostatic Neoplasms

KW - Rad51 Recombinase

KW - Severity of Illness Index

KW - Tumor Markers, Biological

U2 - 10.1111/j.1365-2559.2009.03448.x

DO - 10.1111/j.1365-2559.2009.03448.x

M3 - Article

C2 - 20002770

VL - 55

SP - 696

EP - 704

JO - Histopathology

JF - Histopathology

SN - 0309-0167

IS - 6

ER -