Pain reporting at different body sites is explained by a single underlying genetic factor

Frances M. K. Williams, Tim D. Spector, Alex J. MacGregor

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)


Musculoskeletal pain is reported commonly; however, the extent to which pain in individual body areas reflects the severity of site-specific pathology or a more generalized propensity to feel pain is uncertain. We used a classical twin design to examine the pattern of pain reporting at different body sites among monozygotic (MZ) and dizygotic (DZ) twins to assess its heritability and to examine evidence for a common underlying propensity to report musculoskeletal pain.
Original languageEnglish
Pages (from-to)1753-1755
Number of pages3
Issue number9
Publication statusPublished - Sep 2010


  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Osteoarthritis
  • Pain
  • Pain Measurement
  • Questionnaires
  • Severity of Illness Index
  • Twins
  • Young Adult

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