Pangelin, an Antimycobacterial Coumarin from Ducrosia anethifolia

Michael Stavri; K. Thomas Mathew; Franz Bucar; Simon Gibbons

doi:10.1055/s-2003-45109

Pangelin, an Antimycobacterial Coumarin from Ducrosia anethifolia

Michael Stavri, K. Thomas Mathew, Franz Bucar, Simon Gibbons

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

The aerial parts of Ducrosia anethifolia afforded the monoterpene glucoside 8-debenzoylpaeoniflorin (1) and the prenylated furanocoumarin pangelin {5-[2′′(R)-hydroxy-3′′-methyl-3′′-butenyloxy]furocoumarin} (2). Their structures were determined by extensive 1- and 2-dimensional NMR studies. Compound 2 demonstrated activity against a panel of fast growing mycobacteria, namely Mycobacterium fortuitum, M. aurum, M. phlei and M. smegmatis and minimum inhibitory concentration (MIC) values ranged from 64 - 128 μg/mL. Whilst compounds 1 and 2 have previously been reported as an antihyperglycaemic component from Paeonia lactiflora, and as a constituent of Angelica pancici, respectively, this is the first report of the full 1H- and 13C-NMR data for these natural products.

Original language	English
Pages (from-to)	956-959
Number of pages	4
Journal	Planta Medica
Volume	69
Issue number	10
DOIs	https://doi.org/10.1055/s-2003-45109
Publication status	Published - 1 Oct 2003

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10.1055/s-2003-45109

http://www.thieme-connect.de/DOI/DOI?10.1055/s-2003-45109

Cite this

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title = "Pangelin, an Antimycobacterial Coumarin from Ducrosia anethifolia",

abstract = "The aerial parts of Ducrosia anethifolia afforded the monoterpene glucoside 8-debenzoylpaeoniflorin (1) and the prenylated furanocoumarin pangelin {5-[2′′(R)-hydroxy-3′′-methyl-3′′-butenyloxy]furocoumarin} (2). Their structures were determined by extensive 1- and 2-dimensional NMR studies. Compound 2 demonstrated activity against a panel of fast growing mycobacteria, namely Mycobacterium fortuitum, M. aurum, M. phlei and M. smegmatis and minimum inhibitory concentration (MIC) values ranged from 64 - 128 μg/mL. Whilst compounds 1 and 2 have previously been reported as an antihyperglycaemic component from Paeonia lactiflora, and as a constituent of Angelica pancici, respectively, this is the first report of the full 1H- and 13C-NMR data for these natural products.",

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T1 - Pangelin, an Antimycobacterial Coumarin from Ducrosia anethifolia

AU - Stavri, Michael

AU - Mathew, K. Thomas

AU - Bucar, Franz

AU - Gibbons, Simon

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N2 - The aerial parts of Ducrosia anethifolia afforded the monoterpene glucoside 8-debenzoylpaeoniflorin (1) and the prenylated furanocoumarin pangelin {5-[2′′(R)-hydroxy-3′′-methyl-3′′-butenyloxy]furocoumarin} (2). Their structures were determined by extensive 1- and 2-dimensional NMR studies. Compound 2 demonstrated activity against a panel of fast growing mycobacteria, namely Mycobacterium fortuitum, M. aurum, M. phlei and M. smegmatis and minimum inhibitory concentration (MIC) values ranged from 64 - 128 μg/mL. Whilst compounds 1 and 2 have previously been reported as an antihyperglycaemic component from Paeonia lactiflora, and as a constituent of Angelica pancici, respectively, this is the first report of the full 1H- and 13C-NMR data for these natural products.

AB - The aerial parts of Ducrosia anethifolia afforded the monoterpene glucoside 8-debenzoylpaeoniflorin (1) and the prenylated furanocoumarin pangelin {5-[2′′(R)-hydroxy-3′′-methyl-3′′-butenyloxy]furocoumarin} (2). Their structures were determined by extensive 1- and 2-dimensional NMR studies. Compound 2 demonstrated activity against a panel of fast growing mycobacteria, namely Mycobacterium fortuitum, M. aurum, M. phlei and M. smegmatis and minimum inhibitory concentration (MIC) values ranged from 64 - 128 μg/mL. Whilst compounds 1 and 2 have previously been reported as an antihyperglycaemic component from Paeonia lactiflora, and as a constituent of Angelica pancici, respectively, this is the first report of the full 1H- and 13C-NMR data for these natural products.

U2 - 10.1055/s-2003-45109

DO - 10.1055/s-2003-45109

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