Parallel adaptation of rabbit populations to myxoma virus

Joel M. Alves; Miguel Carneiro; Jade Y.  Cheng; Ana Lemos  de Matos; Masmudur M. Rahman; Liisa  Loog; Paula F.  Campos; Nathan  Wales; Anders  Eriksson; Andrea  Manica; Tanja  Strive; Stephen C. Graham; Sandra  Alfonso; Diana Bell; Laura  Belmont; Jonathan P. Day; Susan J.  Fuller; Stephane  Marchandeau; William J. Palmer; Guillaume Queney; Alison K. Surridge; Filipe G.  Vieira; Grant  McFadden; Rasmus  Nielsen; M. Thomas P. Gilbert; Pedro J.  Esteves; Nuno  Ferrand; Francis M. Jiggins

doi:10.1126/science.aau7285

Parallel adaptation of rabbit populations to myxoma virus

Joel M. Alves, Miguel Carneiro, Jade Y. Cheng, Ana Lemos de Matos, Masmudur M. Rahman, Liisa Loog, Paula F. Campos, Nathan Wales, Anders Eriksson, Andrea Manica, Tanja Strive, Stephen C. Graham, Sandra Alfonso, Diana Bell, Laura Belmont, Jonathan P. Day, Susan J. Fuller, Stephane Marchandeau, William J. Palmer, Guillaume QueneyAlison K. Surridge, Filipe G. Vieira, Grant McFadden, Rasmus Nielsen, M. Thomas P. Gilbert, Pedro J. Esteves, Nuno Ferrand, Francis M. Jiggins

Research output: Contribution to journal › Article › peer-review

105 Citations (Scopus)

Abstract

In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favouring the same alleles in Australia, France and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased its antiviral effect.

Original language	English
Pages (from-to)	1319-1326
Number of pages	8
Journal	Science
Volume	363
Issue number	6433
Early online date	14 Feb 2019
DOIs	https://doi.org/10.1126/science.aau7285
Publication status	Published - 22 Mar 2019

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10.1126/science.aau7285

http://eprints.whiterose.ac.uk/143315/

Diana Bell
- D.Belluea.acuk
- School of Biological Sciences - Emeritus Professor
- Centre for Ecology, Evolution and Conservation - Member
- Water Security Research Centre - Member
Person: Honorary, Research Centre Member

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Alves, J. M., Carneiro, M., Cheng, J. Y., de Matos, A. L., Rahman, M. M., Loog, L., Campos, P. F., Wales, N., Eriksson, A., Manica, A., Strive, T., Graham, S. C., Alfonso, S., Bell, D., Belmont, L., Day, J. P., Fuller, S. J., Marchandeau, S., Palmer, W. J., ... Jiggins, F. M. (2019). Parallel adaptation of rabbit populations to myxoma virus. Science, 363(6433), 1319-1326. https://doi.org/10.1126/science.aau7285

Alves, Joel M. ; Carneiro, Miguel ; Cheng, Jade Y. ; de Matos, Ana Lemos ; Rahman, Masmudur M. ; Loog, Liisa ; Campos, Paula F. ; Wales, Nathan ; Eriksson, Anders ; Manica, Andrea ; Strive, Tanja ; Graham, Stephen C. ; Alfonso, Sandra ; Bell, Diana ; Belmont, Laura ; Day, Jonathan P. ; Fuller, Susan J. ; Marchandeau, Stephane ; Palmer, William J. ; Queney, Guillaume ; Surridge, Alison K. ; Vieira, Filipe G. ; McFadden, Grant ; Nielsen, Rasmus ; Gilbert, M. Thomas P. ; Esteves, Pedro J. ; Ferrand, Nuno ; Jiggins, Francis M. / Parallel adaptation of rabbit populations to myxoma virus. In: Science. 2019 ; Vol. 363, No. 6433. pp. 1319-1326.

@article{a976402e2d4f43439d5887af234ffb1d,

title = "Parallel adaptation of rabbit populations to myxoma virus",

abstract = "In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favouring the same alleles in Australia, France and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased its antiviral effect.",

author = "Alves, {Joel M.} and Miguel Carneiro and Cheng, {Jade Y.} and {de Matos}, {Ana Lemos} and Rahman, {Masmudur M.} and Liisa Loog and Campos, {Paula F.} and Nathan Wales and Anders Eriksson and Andrea Manica and Tanja Strive and Graham, {Stephen C.} and Sandra Alfonso and Diana Bell and Laura Belmont and Day, {Jonathan P.} and Fuller, {Susan J.} and Stephane Marchandeau and Palmer, {William J.} and Guillaume Queney and Surridge, {Alison K.} and Vieira, {Filipe G.} and Grant McFadden and Rasmus Nielsen and Gilbert, {M. Thomas P.} and Esteves, {Pedro J.} and Nuno Ferrand and Jiggins, {Francis M.}",

year = "2019",

month = mar,

day = "22",

doi = "10.1126/science.aau7285",

language = "English",

volume = "363",

pages = "1319--1326",

journal = "Science",

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Alves, JM, Carneiro, M, Cheng, JY, de Matos, AL, Rahman, MM, Loog, L, Campos, PF, Wales, N, Eriksson, A, Manica, A, Strive, T, Graham, SC, Alfonso, S, Bell, D, Belmont, L, Day, JP, Fuller, SJ, Marchandeau, S, Palmer, WJ, Queney, G, Surridge, AK, Vieira, FG, McFadden, G, Nielsen, R, Gilbert, MTP, Esteves, PJ, Ferrand, N & Jiggins, FM 2019, 'Parallel adaptation of rabbit populations to myxoma virus', Science, vol. 363, no. 6433, pp. 1319-1326. https://doi.org/10.1126/science.aau7285

Parallel adaptation of rabbit populations to myxoma virus. / Alves, Joel M.; Carneiro, Miguel; Cheng, Jade Y. ; de Matos, Ana Lemos ; Rahman, Masmudur M.; Loog, Liisa ; Campos, Paula F. ; Wales, Nathan ; Eriksson, Anders ; Manica, Andrea ; Strive, Tanja ; Graham, Stephen C.; Alfonso, Sandra ; Bell, Diana; Belmont, Laura ; Day, Jonathan P.; Fuller, Susan J. ; Marchandeau, Stephane ; Palmer, William J.; Queney, Guillaume; Surridge, Alison K.; Vieira, Filipe G. ; McFadden, Grant ; Nielsen, Rasmus ; Gilbert, M. Thomas P.; Esteves, Pedro J. ; Ferrand, Nuno ; Jiggins, Francis M.

In: Science, Vol. 363, No. 6433, 22.03.2019, p. 1319-1326.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Parallel adaptation of rabbit populations to myxoma virus

AU - Alves, Joel M.

AU - Carneiro, Miguel

AU - Cheng, Jade Y.

AU - de Matos, Ana Lemos

AU - Rahman, Masmudur M.

AU - Loog, Liisa

AU - Campos, Paula F.

AU - Wales, Nathan

AU - Eriksson, Anders

AU - Manica, Andrea

AU - Strive, Tanja

AU - Graham, Stephen C.

AU - Alfonso, Sandra

AU - Bell, Diana

AU - Belmont, Laura

AU - Day, Jonathan P.

AU - Fuller, Susan J.

AU - Marchandeau, Stephane

AU - Palmer, William J.

AU - Queney, Guillaume

AU - Surridge, Alison K.

AU - Vieira, Filipe G.

AU - McFadden, Grant

AU - Nielsen, Rasmus

AU - Gilbert, M. Thomas P.

AU - Esteves, Pedro J.

AU - Ferrand, Nuno

AU - Jiggins, Francis M.

PY - 2019/3/22

Y1 - 2019/3/22

N2 - In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favouring the same alleles in Australia, France and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased its antiviral effect.

AB - In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favouring the same alleles in Australia, France and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased its antiviral effect.

U2 - 10.1126/science.aau7285

DO - 10.1126/science.aau7285

M3 - Article

VL - 363

SP - 1319

EP - 1326

JO - Science

JF - Science

SN - 0036-8075

IS - 6433

ER -

Parallel adaptation of rabbit populations to myxoma virus

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