Pathfinders and trailblazers: a prokaryotic targeting system for transport of folded proteins

Frank Sargent, Ben C. Berks, Tracy Palmer

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


The twin-arginine (Tat) protein translocase is a highly unusual protein transport machine that is dedicated to the movement of folded proteins across the bacterial cytoplasmic membrane. Proteins are targeted to the Tat pathway by means of N-terminal signal peptides harbouring a distinctive twin-arginine motif. In this minireview, we describe our current knowledge of the Tat system, paying particular attention to the function of the TatA protein and to the often overlooked step of signal peptide cleavage.
Original languageEnglish
Pages (from-to)198–207
Number of pages10
JournalFEMS Microbiology Letters
Issue number2
Publication statusPublished - 2006

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