Peculiar antibody reactivity to human connexin 37 and its microbial mimics in patients with Crohn's disease

Andreas Koutsoumpas, Dimitrios Polymeros, Zacharias Tsiamoulos, Daniel Smyk, George Karamanolis, Konstantinos Triantafyllou, E I Rigopoulou, Alastair Forbes, Diego Vergani, Dimitrios P Bogdanos, Spiros D Ladas

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We found that pooled Crohn's disease (CD) sera strongly react with a human gap-junction connexin 37 (Cx37) peptide and tested for anti-Cx37 antibody reactivity in sera from CD patients and controls. We also investigated whether peptide-recognition is due to Cx37/microbial molecular mimicry.
Original languageEnglish
Pages (from-to)101-9
Number of pages9
JournalJournal of Crohn's & Colitis
Volume5
Issue number2
DOIs
Publication statusPublished - Apr 2011

Keywords

  • Adult
  • Antigen-Antibody Reactions
  • Bacterial Proteins
  • Connexins
  • Crohn Disease
  • Enterovirus B, Human
  • Enterovirus C, Human
  • Female
  • Humans
  • Lactococcus lactis
  • Male
  • Middle Aged
  • Molecular Mimicry
  • Sequence Homology, Amino Acid
  • Viral Proteins

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