Peculiar antibody reactivity to human connexin 37 and its microbial mimics in patients with Crohn's disease

Andreas Koutsoumpas; Dimitrios Polymeros; Zacharias Tsiamoulos; Daniel Smyk; George Karamanolis; Konstantinos Triantafyllou; E I Rigopoulou; Alastair Forbes; Diego Vergani; Dimitrios P Bogdanos; Spiros D Ladas

doi:10.1016/j.crohns.2010.10.009

Peculiar antibody reactivity to human connexin 37 and its microbial mimics in patients with Crohn's disease

Andreas Koutsoumpas, Dimitrios Polymeros, Zacharias Tsiamoulos, Daniel Smyk, George Karamanolis, Konstantinos Triantafyllou, E I Rigopoulou, Alastair Forbes, Diego Vergani, Dimitrios P Bogdanos, Spiros D Ladas

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

We found that pooled Crohn's disease (CD) sera strongly react with a human gap-junction connexin 37 (Cx37) peptide and tested for anti-Cx37 antibody reactivity in sera from CD patients and controls. We also investigated whether peptide-recognition is due to Cx37/microbial molecular mimicry.

Original language	English
Pages (from-to)	101-9
Number of pages	9
Journal	Journal of Crohn's & Colitis
Volume	5
Issue number	2
DOIs	https://doi.org/10.1016/j.crohns.2010.10.009
Publication status	Published - Apr 2011

Keywords

Adult
Antigen-Antibody Reactions
Bacterial Proteins
Connexins
Crohn Disease
Enterovirus B, Human
Enterovirus C, Human
Female
Humans
Lactococcus lactis
Male
Middle Aged
Molecular Mimicry
Sequence Homology, Amino Acid
Viral Proteins

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.crohns.2010.10.009

Cite this

Koutsoumpas, A., Polymeros, D., Tsiamoulos, Z., Smyk, D., Karamanolis, G., Triantafyllou, K., Rigopoulou, E. I., Forbes, A., Vergani, D., Bogdanos, D. P., & Ladas, S. D. (2011). Peculiar antibody reactivity to human connexin 37 and its microbial mimics in patients with Crohn's disease. Journal of Crohn's & Colitis, 5(2), 101-9. https://doi.org/10.1016/j.crohns.2010.10.009

Koutsoumpas, Andreas ; Polymeros, Dimitrios ; Tsiamoulos, Zacharias ; Smyk, Daniel ; Karamanolis, George ; Triantafyllou, Konstantinos ; Rigopoulou, E I ; Forbes, Alastair ; Vergani, Diego ; Bogdanos, Dimitrios P ; Ladas, Spiros D. / Peculiar antibody reactivity to human connexin 37 and its microbial mimics in patients with Crohn's disease. In: Journal of Crohn's & Colitis. 2011 ; Vol. 5, No. 2. pp. 101-9.

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title = "Peculiar antibody reactivity to human connexin 37 and its microbial mimics in patients with Crohn's disease",

abstract = "We found that pooled Crohn's disease (CD) sera strongly react with a human gap-junction connexin 37 (Cx37) peptide and tested for anti-Cx37 antibody reactivity in sera from CD patients and controls. We also investigated whether peptide-recognition is due to Cx37/microbial molecular mimicry.",

keywords = "Adult, Antigen-Antibody Reactions, Bacterial Proteins, Connexins, Crohn Disease, Enterovirus B, Human, Enterovirus C, Human, Female, Humans, Lactococcus lactis, Male, Middle Aged, Molecular Mimicry, Sequence Homology, Amino Acid, Viral Proteins",

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Peculiar antibody reactivity to human connexin 37 and its microbial mimics in patients with Crohn's disease. / Koutsoumpas, Andreas; Polymeros, Dimitrios; Tsiamoulos, Zacharias; Smyk, Daniel; Karamanolis, George; Triantafyllou, Konstantinos; Rigopoulou, E I; Forbes, Alastair; Vergani, Diego; Bogdanos, Dimitrios P; Ladas, Spiros D.

In: Journal of Crohn's & Colitis, Vol. 5, No. 2, 04.2011, p. 101-9.

Research output: Contribution to journal › Article › peer-review

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AU - Koutsoumpas, Andreas

AU - Polymeros, Dimitrios

AU - Tsiamoulos, Zacharias

AU - Smyk, Daniel

AU - Karamanolis, George

AU - Triantafyllou, Konstantinos

AU - Rigopoulou, E I

AU - Forbes, Alastair

AU - Vergani, Diego

AU - Bogdanos, Dimitrios P

AU - Ladas, Spiros D

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AB - We found that pooled Crohn's disease (CD) sera strongly react with a human gap-junction connexin 37 (Cx37) peptide and tested for anti-Cx37 antibody reactivity in sera from CD patients and controls. We also investigated whether peptide-recognition is due to Cx37/microbial molecular mimicry.

KW - Adult

KW - Antigen-Antibody Reactions

KW - Bacterial Proteins

KW - Connexins

KW - Crohn Disease

KW - Enterovirus B, Human

KW - Enterovirus C, Human

KW - Female

KW - Humans

KW - Lactococcus lactis

KW - Male

KW - Middle Aged

KW - Molecular Mimicry

KW - Sequence Homology, Amino Acid

KW - Viral Proteins

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JO - Journal of Crohn's & Colitis

JF - Journal of Crohn's & Colitis

SN - 1873-9946

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