Pederins, mycalamides, onnamides and theopederins: Distinctive polyketide families with intriguing therapeutic potentialities

In this comprehensive review article, an in-depth exploration over the period from 1949 to 2023 is presented, focusing on the discovery, chemistry, biosynthesis and therapeutic potentials of pederin and related polyketides. Herein, we extensively documented a diverse collection of 45 isolated compounds with varied chemical structures, systematically organized based on their isolation sources. Furthermore, it includes an updated detailed overview of their reported pharmacological activities whenever applicable. Additionally, the article briefly discusses insights into the proposed biosynthetic pathway of these intriguing polyketides.