Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers

Zoë Rachael Goddard, Andrew Michael Beekman, Marco M. D. Cominetti, Maria A. O'Connell, Isabelle Chambrier, Michael J. Cook, Maria J. Marin, David A. Russell, Mark Searcey (Lead Author)

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)
27 Downloads (Pure)

Abstract

Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity.
Original languageEnglish
Pages (from-to)288-292
Number of pages5
JournalRSC Medicinal Chemistry
Volume12
Issue number2
Early online date19 Nov 2020
DOIs
Publication statusPublished - 1 Feb 2021

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