Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers

Zoë Rachael Goddard; Andrew Michael Beekman; Marco M. D. Cominetti; Maria A. O'Connell; Isabelle Chambrier; Michael J. Cook; Maria J. Marin; David A. Russell; Mark Searcey

doi:10.1039/D0MD00284D

Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers

Zoë Rachael Goddard, Andrew Michael Beekman, Marco M. D. Cominetti, Maria A. O'Connell, Isabelle Chambrier, Michael J. Cook, Maria J. Marin, David A. Russell, Mark Searcey (Lead Author)

Research output: Contribution to journal › Article › peer-review

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Abstract

Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity.

Original language	English
Pages (from-to)	288-292
Number of pages	5
Journal	RSC Medicinal Chemistry
Volume	12
Issue number	2
Early online date	19 Nov 2020
DOIs	https://doi.org/10.1039/D0MD00284D
Publication status	Published - 1 Feb 2021

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10.1039/D0MD00284DLicence: CC BY-NC

Published_VersionFinal published version, 1.45 MBLicence: CC BY-NC

Andrew Beekman
- A.Beekmanuea.acuk
- School of Chemistry, Pharmacy and Pharmacology - Associate Professor in Medicinal Chemistry
Person: Academic, Teaching & Research
Maria J. Marin
- M.Marin-Altabauea.acuk
- School of Chemistry, Pharmacy and Pharmacology - Associate Professor in Analytical Chemistry
- Centre for Photonics and Quantum Science - Member
- Chemistry of Life Processes - Member
- Chemistry of Light and Energy - Member
- Chemistry of Materials and Catalysis - Member
Person: Research Group Member, Academic, Teaching & Research
David Russell
- D.Russelluea.acuk
- School of Chemistry, Pharmacy and Pharmacology - Emeritus Professor
Person: Honorary

Cite this

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title = "Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers",

abstract = "Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity.",

author = "Goddard, {Zo{\"e} Rachael} and Beekman, {Andrew Michael} and Cominetti, {Marco M. D.} and O'Connell, {Maria A.} and Isabelle Chambrier and Cook, {Michael J.} and Marin, {Maria J.} and Russell, {David A.} and Mark Searcey",

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doi = "10.1039/D0MD00284D",

language = "English",

volume = "12",

pages = "288--292",

journal = "RSC Medicinal Chemistry",

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TY - JOUR

T1 - Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers

AU - Goddard, Zoë Rachael

AU - Beekman, Andrew Michael

AU - Cominetti, Marco M. D.

AU - O'Connell, Maria A.

AU - Chambrier, Isabelle

AU - Cook, Michael J.

AU - Marin, Maria J.

AU - Russell, David A.

AU - Searcey, Mark

PY - 2021/2/1

Y1 - 2021/2/1

N2 - Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity.

AB - Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity.

U2 - 10.1039/D0MD00284D

DO - 10.1039/D0MD00284D

M3 - Article

SN - 2632-8682

VL - 12

SP - 288

EP - 292

JO - RSC Medicinal Chemistry

JF - RSC Medicinal Chemistry

IS - 2

ER -

Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers

Abstract

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Profiles

Andrew Beekman

Maria J. Marin

David Russell

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