Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers

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Abstract

Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity.
Original languageEnglish
Pages (from-to)288-292
Number of pages5
JournalRSC Medicinal Chemistry
Volume12
Issue number2
Early online date19 Nov 2020
DOIs
Publication statusPublished - 1 Feb 2021

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