Peritumoral diffusion tensor imaging of high-grade gliomas and metastatic brain tumors

Stanley Lu, Daniel Ahn, Glyn Johnson, Soonmee Cha

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353 Citations (Scopus)


BACKGROUND AND PURPOSE: Diffusion tensor imaging (DTI) is an advanced MR technique that describes the movement of water molecules by using two metrics, mean diffusivity (MD), and fractional anisotropy (FA), which represent the magnitude and directionality of water diffusion, respectively. We hypothesize that alterations in these values within the tissue surrounding brain tumors reflect combinations of increased water content and tumor infiltration and that these changes can be used to differentiate high-grade gliomas from metastatic lesions. METHODS: DTI was performed in 12 patients with high-grade gliomas and in 12 with metastatic lesions. DTI measurements were obtained from regions of interest (ROIs) placed on normal-appearing white matter and on the vasogenic edema, the T2 signal intensity abnormality surrounding each tumor. RESULTS: The peritumoral region of both gliomas and metastatic tumors displayed significant increases in MD (P
Original languageEnglish
Pages (from-to)937-941
Number of pages5
JournalAmerican Journal of Neuroradiology
Issue number5
Publication statusPublished - 2003

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