Perspectives on the Trypanosoma cruzi-host cell receptor interaction

Fernando Villalta; Julio Scharfstein; Anthony W. Ashton; Kevin M. Tyler; Fangxia Guan; Shankar Mukherjee; Maria F. Lima; Sandra Alvarez; Louis M. Weiss; Huan Huang; Fabiana S. Machado; Herbert B. Tanowitz

doi:10.1007/s00436-009-1383-3

Perspectives on the Trypanosoma cruzi-host cell receptor interaction

Fernando Villalta, Julio Scharfstein, Anthony W. Ashton, Kevin M. Tyler, Fangxia Guan, Shankar Mukherjee, Maria F. Lima, Sandra Alvarez, Louis M. Weiss, Huan Huang, Fabiana S. Machado, Herbert B. Tanowitz

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Chagas disease is caused by the parasite Trypanosoma cruzi. The critical initial event is the interaction of the trypomastigote form of the parasite with host receptors. This review highlights recent observations concerning these interactions. Some of the key receptors considered are those for thromboxane, bradykinin, and for the nerve growth factor TrKA. Other important receptors such as galectin-3, thrombospondin, and laminin are also discussed. Investigation into the molecular biology and cell biology of host receptors for T. cruzi may provide novel therapeutic targets.

Original language	English
Pages (from-to)	1251-1260
Number of pages	10
Journal	Parasitology Research
Volume	104
Issue number	6
DOIs	https://doi.org/10.1007/s00436-009-1383-3
Publication status	Published - May 2009

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10.1007/s00436-009-1383-3

Cite this

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title = "Perspectives on the Trypanosoma cruzi-host cell receptor interaction",

abstract = "Chagas disease is caused by the parasite Trypanosoma cruzi. The critical initial event is the interaction of the trypomastigote form of the parasite with host receptors. This review highlights recent observations concerning these interactions. Some of the key receptors considered are those for thromboxane, bradykinin, and for the nerve growth factor TrKA. Other important receptors such as galectin-3, thrombospondin, and laminin are also discussed. Investigation into the molecular biology and cell biology of host receptors for T. cruzi may provide novel therapeutic targets.",

author = "Fernando Villalta and Julio Scharfstein and Ashton, {Anthony W.} and Tyler, {Kevin M.} and Fangxia Guan and Shankar Mukherjee and Lima, {Maria F.} and Sandra Alvarez and Weiss, {Louis M.} and Huan Huang and Machado, {Fabiana S.} and Tanowitz, {Herbert B.}",

year = "2009",

month = may,

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language = "English",

volume = "104",

pages = "1251--1260",

journal = "Parasitology Research",

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T1 - Perspectives on the Trypanosoma cruzi-host cell receptor interaction

AU - Villalta, Fernando

AU - Scharfstein, Julio

AU - Ashton, Anthony W.

AU - Tyler, Kevin M.

AU - Guan, Fangxia

AU - Mukherjee, Shankar

AU - Lima, Maria F.

AU - Alvarez, Sandra

AU - Weiss, Louis M.

AU - Huang, Huan

AU - Machado, Fabiana S.

AU - Tanowitz, Herbert B.

PY - 2009/5

Y1 - 2009/5

N2 - Chagas disease is caused by the parasite Trypanosoma cruzi. The critical initial event is the interaction of the trypomastigote form of the parasite with host receptors. This review highlights recent observations concerning these interactions. Some of the key receptors considered are those for thromboxane, bradykinin, and for the nerve growth factor TrKA. Other important receptors such as galectin-3, thrombospondin, and laminin are also discussed. Investigation into the molecular biology and cell biology of host receptors for T. cruzi may provide novel therapeutic targets.

AB - Chagas disease is caused by the parasite Trypanosoma cruzi. The critical initial event is the interaction of the trypomastigote form of the parasite with host receptors. This review highlights recent observations concerning these interactions. Some of the key receptors considered are those for thromboxane, bradykinin, and for the nerve growth factor TrKA. Other important receptors such as galectin-3, thrombospondin, and laminin are also discussed. Investigation into the molecular biology and cell biology of host receptors for T. cruzi may provide novel therapeutic targets.

U2 - 10.1007/s00436-009-1383-3

DO - 10.1007/s00436-009-1383-3

M3 - Article

VL - 104

SP - 1251

EP - 1260

JO - Parasitology Research

JF - Parasitology Research

SN - 0932-0113

IS - 6

ER -