Perspectives on the Trypanosoma cruzi-host cell receptor interaction

Fernando Villalta, Julio Scharfstein, Anthony W. Ashton, Kevin M. Tyler, Fangxia Guan, Shankar Mukherjee, Maria F. Lima, Sandra Alvarez, Louis M. Weiss, Huan Huang, Fabiana S. Machado, Herbert B. Tanowitz

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34 Citations (Scopus)


Chagas disease is caused by the parasite Trypanosoma cruzi. The critical initial event is the interaction of the trypomastigote form of the parasite with host receptors. This review highlights recent observations concerning these interactions. Some of the key receptors considered are those for thromboxane, bradykinin, and for the nerve growth factor TrKA. Other important receptors such as galectin-3, thrombospondin, and laminin are also discussed. Investigation into the molecular biology and cell biology of host receptors for T. cruzi may provide novel therapeutic targets.
Original languageEnglish
Pages (from-to)1251-1260
Number of pages10
JournalParasitology Research
Issue number6
Publication statusPublished - May 2009

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