Pertussis antibody responses in infants born to mothers vaccinated at different time points in pregnancy

Olwenn Daniel; Sashank Srikanth; Paul Clarke; Kirsty Le Doare; Paul T. Heath; Christine E. Jones; Tim Scorrer; Matthew Snape; Anna Calvert

doi:10.1016/j.vaccine.2025.127481

Pertussis antibody responses in infants born to mothers vaccinated at different time points in pregnancy

Olwenn Daniel, Sashank Srikanth, Paul Clarke, Kirsty Le Doare, Paul T. Heath, Christine E. Jones, Tim Scorrer, Matthew Snape, Anna Calvert

Norwich Medical School

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Abstract

The optimal timing of pertussis vaccination in pregnancy is debated, especially to maximise antibody concentrations in infants born preterm. This study investigated immunoglobulin G (IgG) in preterm infants at 5 and 12 months, whose mothers had received a pertussis-containing vaccine at different gestations or were unvaccinated. Results show that vaccination in the early-mid second trimester may result in increased FHA specific IgG concentrations in preterm infants at 5 and 12 months. The BEAR PAW study used residual serum samples from the BEAR Men B study (Babies born Early Antibody Response to Men B vaccination (NCT03125616)).

Original language	English
Article number	127481
Journal	Vaccine
Volume	62
Early online date	12 Jul 2025
DOIs	https://doi.org/10.1016/j.vaccine.2025.127481
Publication status	Published - 30 Aug 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bordetella pertussis
Immunoglobulin G
Multiplex
Preterm
Serology
Vaccine

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Cite this

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title = "Pertussis antibody responses in infants born to mothers vaccinated at different time points in pregnancy",

abstract = "The optimal timing of pertussis vaccination in pregnancy is debated, especially to maximise antibody concentrations in infants born preterm. This study investigated immunoglobulin G (IgG) in preterm infants at 5 and 12 months, whose mothers had received a pertussis-containing vaccine at different gestations or were unvaccinated. Results show that vaccination in the early-mid second trimester may result in increased FHA specific IgG concentrations in preterm infants at 5 and 12 months. The BEAR PAW study used residual serum samples from the BEAR Men B study (Babies born Early Antibody Response to Men B vaccination (NCT03125616)).",

keywords = "Bordetella pertussis, Immunoglobulin G, Multiplex, Preterm, Serology, Vaccine",

author = "Olwenn Daniel and Sashank Srikanth and Paul Clarke and {Le Doare}, Kirsty and Heath, {Paul T.} and Jones, {Christine E.} and Tim Scorrer and Matthew Snape and Anna Calvert",

note = "Data availability: Data collected for the study, including individual (deidentified) participant data and a data dictionary defining each field in the set, can be made available for suitable applications submitted to the Chief Investigator ([email protected]). Additional related documents are available on request.",

year = "2025",

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doi = "10.1016/j.vaccine.2025.127481",

language = "English",

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T1 - Pertussis antibody responses in infants born to mothers vaccinated at different time points in pregnancy

AU - Daniel, Olwenn

AU - Srikanth, Sashank

AU - Clarke, Paul

AU - Le Doare, Kirsty

AU - Heath, Paul T.

AU - Jones, Christine E.

AU - Scorrer, Tim

AU - Snape, Matthew

AU - Calvert, Anna

N1 - Data availability: Data collected for the study, including individual (deidentified) participant data and a data dictionary defining each field in the set, can be made available for suitable applications submitted to the Chief Investigator ([email protected]). Additional related documents are available on request.

PY - 2025/8/30

Y1 - 2025/8/30

N2 - The optimal timing of pertussis vaccination in pregnancy is debated, especially to maximise antibody concentrations in infants born preterm. This study investigated immunoglobulin G (IgG) in preterm infants at 5 and 12 months, whose mothers had received a pertussis-containing vaccine at different gestations or were unvaccinated. Results show that vaccination in the early-mid second trimester may result in increased FHA specific IgG concentrations in preterm infants at 5 and 12 months. The BEAR PAW study used residual serum samples from the BEAR Men B study (Babies born Early Antibody Response to Men B vaccination (NCT03125616)).

AB - The optimal timing of pertussis vaccination in pregnancy is debated, especially to maximise antibody concentrations in infants born preterm. This study investigated immunoglobulin G (IgG) in preterm infants at 5 and 12 months, whose mothers had received a pertussis-containing vaccine at different gestations or were unvaccinated. Results show that vaccination in the early-mid second trimester may result in increased FHA specific IgG concentrations in preterm infants at 5 and 12 months. The BEAR PAW study used residual serum samples from the BEAR Men B study (Babies born Early Antibody Response to Men B vaccination (NCT03125616)).

KW - Bordetella pertussis

KW - Immunoglobulin G

KW - Multiplex

KW - Preterm

KW - Serology

KW - Vaccine

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VL - 62

JO - Vaccine

JF - Vaccine

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ER -

Pertussis antibody responses in infants born to mothers vaccinated at different time points in pregnancy

Abstract

UN SDGs

Keywords

Access to Document

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