Pharmacology and therapeutic role of inorganic nitrite and nitrate in vasodilatation

J C Bailey, M Feelisch, J D Horowitz, M P Frenneaux, M Madhani

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43 Citations (Scopus)


Nitrite has emerged as an important bioactive molecule that can be biotransformed to nitric oxide (NO) related metabolites in normoxia and reduced to NO under hypoxic and acidic conditions to exert vasodilatory effects and confer a variety of other benefits to the cardiovascular system. Abundant research is currently underway to understand the mechanisms involved and define the role of nitrite in health and disease. In this review we discuss the impact of nitrite and dietary nitrate on vascular function and the potential therapeutic role of nitrite in acute heart failure.
Original languageEnglish
Pages (from-to)303-320
Number of pages18
JournalPharmacology & Therapeutics
Issue number3
Early online date30 Jun 2014
Publication statusPublished - 1 Dec 2014

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