Phosphorylation-regulated activation of the Arabidopsis RRS1-R/RPS4 immune receptor complex reveals two distinct effector recognition mechanisms

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The Arabidopsis RRS1-R/RPS4 immune receptor complex responds to bacterial effectors AvrRps4 and PopP2. Guo et al. show that effector-enhanced RRS1 N- and C-terminal proximity comprises a critical reconfiguration step involved in derepression of the complex. Further, RRS1-R C-terminal phosphorylation-dependent conformational reconfigurations distinguish responsiveness to the two effectors.

Original languageEnglish
Pages (from-to)769-781.e6
JournalCell Host & Microbe
Issue number5
Early online date31 Mar 2020
Publication statusPublished - 13 May 2020


  • acetylation
  • effector-triggered immunity
  • integrated decoy
  • paired NLR immune receptors
  • phosphorylation
  • plant-disease resistance

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