Photosensitizer efficacy of non-peripheral substituted alkylbenzopyridoporphyrazines for photodynamic therapy of cancer

Keiichi Sakamoto, Taku Kato, Tomomi Kawaguchi, Eiko Ohno-Okumura, Toshiyuki Urano, Tsuguo Yamaoka, Shota Suzuki, Michael J. Cook

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The triplet state of zinc non-peripheral substituted alkylbenzopyridoporphyrazines and position isomers were measured, using laser-flash photolysis in poly(methyl methacrylate) film. The triplet lifetime increased with an increasing pyridine number in the molecule. The lowest symmetric isomer having two pyridine rings in the molecule showed the longest triplet state lifetime. The compound was suitable for the use the photosensitizer as a photodynamic therapy of cancer. (C) 2002 Elsevier Science B.V. All rights reserved.
Original languageEnglish
Pages (from-to)245-252
Number of pages8
JournalJournal of Photochemistry and Photobiology A: Chemistry
Issue number1-3
Publication statusPublished - 2002

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