Photosensitizer efficacy of non-peripheral substituted alkylbenzopyridoporphyrazines for photodynamic therapy of cancer

Keiichi Sakamoto; Taku Kato; Tomomi Kawaguchi; Eiko Ohno-Okumura; Toshiyuki Urano; Tsuguo Yamaoka; Shota Suzuki; Michael J. Cook

doi:10.1016/S1010-6030(02)00292-7

Photosensitizer efficacy of non-peripheral substituted alkylbenzopyridoporphyrazines for photodynamic therapy of cancer

Keiichi Sakamoto, Taku Kato, Tomomi Kawaguchi, Eiko Ohno-Okumura, Toshiyuki Urano, Tsuguo Yamaoka, Shota Suzuki, Michael J. Cook

School of Chemistry

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

The triplet state of zinc non-peripheral substituted alkylbenzopyridoporphyrazines and position isomers were measured, using laser-flash photolysis in poly(methyl methacrylate) film. The triplet lifetime increased with an increasing pyridine number in the molecule. The lowest symmetric isomer having two pyridine rings in the molecule showed the longest triplet state lifetime. The compound was suitable for the use the photosensitizer as a photodynamic therapy of cancer. (C) 2002 Elsevier Science B.V. All rights reserved.

Original language	English
Pages (from-to)	245-252
Number of pages	8
Journal	Journal of Photochemistry and Photobiology A: Chemistry
Volume	153
Issue number	1-3
DOIs	https://doi.org/10.1016/S1010-6030(02)00292-7
Publication status	Published - 2002

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10.1016/S1010-6030(02)00292-7

Cite this

@article{5d6857ee06fb435ab9a1ff60649f79df,

title = "Photosensitizer efficacy of non-peripheral substituted alkylbenzopyridoporphyrazines for photodynamic therapy of cancer",

abstract = "The triplet state of zinc non-peripheral substituted alkylbenzopyridoporphyrazines and position isomers were measured, using laser-flash photolysis in poly(methyl methacrylate) film. The triplet lifetime increased with an increasing pyridine number in the molecule. The lowest symmetric isomer having two pyridine rings in the molecule showed the longest triplet state lifetime. The compound was suitable for the use the photosensitizer as a photodynamic therapy of cancer. (C) 2002 Elsevier Science B.V. All rights reserved.",

author = "Keiichi Sakamoto and Taku Kato and Tomomi Kawaguchi and Eiko Ohno-Okumura and Toshiyuki Urano and Tsuguo Yamaoka and Shota Suzuki and Cook, {Michael J.}",

year = "2002",

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language = "English",

volume = "153",

pages = "245--252",

journal = "Journal of Photochemistry and Photobiology A: Chemistry",

issn = "1010-6030",

publisher = "Elsevier",

number = "1-3",

}

Photosensitizer efficacy of non-peripheral substituted alkylbenzopyridoporphyrazines for photodynamic therapy of cancer. / Sakamoto, Keiichi; Kato, Taku; Kawaguchi, Tomomi; Ohno-Okumura, Eiko; Urano, Toshiyuki; Yamaoka, Tsuguo; Suzuki, Shota; Cook, Michael J.

In: Journal of Photochemistry and Photobiology A: Chemistry, Vol. 153, No. 1-3, 2002, p. 245-252.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Photosensitizer efficacy of non-peripheral substituted alkylbenzopyridoporphyrazines for photodynamic therapy of cancer

AU - Sakamoto, Keiichi

AU - Kato, Taku

AU - Kawaguchi, Tomomi

AU - Ohno-Okumura, Eiko

AU - Urano, Toshiyuki

AU - Yamaoka, Tsuguo

AU - Suzuki, Shota

AU - Cook, Michael J.

PY - 2002

Y1 - 2002

N2 - The triplet state of zinc non-peripheral substituted alkylbenzopyridoporphyrazines and position isomers were measured, using laser-flash photolysis in poly(methyl methacrylate) film. The triplet lifetime increased with an increasing pyridine number in the molecule. The lowest symmetric isomer having two pyridine rings in the molecule showed the longest triplet state lifetime. The compound was suitable for the use the photosensitizer as a photodynamic therapy of cancer. (C) 2002 Elsevier Science B.V. All rights reserved.

AB - The triplet state of zinc non-peripheral substituted alkylbenzopyridoporphyrazines and position isomers were measured, using laser-flash photolysis in poly(methyl methacrylate) film. The triplet lifetime increased with an increasing pyridine number in the molecule. The lowest symmetric isomer having two pyridine rings in the molecule showed the longest triplet state lifetime. The compound was suitable for the use the photosensitizer as a photodynamic therapy of cancer. (C) 2002 Elsevier Science B.V. All rights reserved.

U2 - 10.1016/S1010-6030(02)00292-7

DO - 10.1016/S1010-6030(02)00292-7

M3 - Article

VL - 153

SP - 245

EP - 252

JO - Journal of Photochemistry and Photobiology A: Chemistry

JF - Journal of Photochemistry and Photobiology A: Chemistry

SN - 1010-6030

IS - 1-3

ER -